CD29
整聯蛋白β-1(英語:Integrin beta-1),也被稱為 CD29 是一個由人類基因 ITGB1 編碼的蛋白質[5]。CD29是整合素極晚期抗原受體的一個亞基。它與α-3亞基形成整合素α3β1,作為神經生長因子1和絡絲蛋白的受體。在心肌和骨骼肌種,整聯蛋白β-1會選擇性表現為β-1D蛋白質異形體。
相互作用
CD29已經顯示出與下列蛋白質交互作用:
參考文獻
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl, May 2017
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- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
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- ^ 12.0 12.1 van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, Shapiro SS, Sonnenberg A. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. The Journal of Cell Biology. Jan 2002, 156 (2): 361–76. PMC 2199218 . PMID 11807098. doi:10.1083/jcb.200103037.
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- ^ Chang DD, Wong C, Smith H, Liu J. ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin. The Journal of Cell Biology. Sep 1997, 138 (5): 1149–57. PMC 2136751 . PMID 9281591. doi:10.1083/jcb.138.5.1149.
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- ^ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y. Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. Journal of Cell Science. Jul 2000, 113 (13): 2385–97. PMID 10852818.
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- ^ Fournier HN, Dupé-Manet S, Bouvard D, Lacombe ML, Marie C, Block MR, Albiges-Rizo C. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. The Journal of Biological Chemistry. Jun 2002, 277 (23): 20895–902. PMID 11919189. doi:10.1074/jbc.M200200200.
- ^ Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and Cellular Biology. Aug 2002, 22 (16): 5897–911. PMC 133968 . PMID 12138200. doi:10.1128/MCB.22.16.5897-5911.2002.
- ^ Tapley P, Horwitz A, Buck C, Duggan K, Rohrschneider L. Integrins isolated from Rous sarcoma virus-transformed chicken embryo fibroblasts. Oncogene. Mar 1989, 4 (3): 325–33. PMID 2468126.
- ^ Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature. 1986, 320 (6062): 531–3. PMID 2938015. doi:10.1038/320531a0.
- ^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME. NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins. The Journal of Biological Chemistry. Nov 1997, 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181.
- ^ Han DC, Rodriguez LG, Guan JL. Identification of a novel interaction between integrin beta1 and 14-3-3beta. Oncogene. Jan 2001, 20 (3): 346–57. PMID 11313964. doi:10.1038/sj.onc.1204068.
外部連結
- 醫學主題詞表(MeSH):CD29+Antigen
- Human ITGB1 genome location and ITGB1 gene details page in the UCSC Genome Browser.