CXCR5
| Chemokine (C-X-C motif) receptor 5 趋化因子（C-X-C基序）受体5 | |||
|---|---|---|---|
| 标识 | |||
| 代号 | CXCR5; BLR1; CD185; MDR15 | ||
| 扩展标识 | 遗传学：601613 鼠基因：103567 同源基因：1298 IUPHAR: CXCR5 ChEMBL: 1075315 GeneCards: CXCR5 Gene | ||
| RNA表达模式 | |||
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| 更多表达数据 | |||
| 直系同源体 | |||
| 物种 | 人类 | 小鼠 | |
| Entrez | 643 | 12145 | |
| Ensembl | ENSG00000160683 | ENSMUSG00000047880 | |
| UniProt | P32302 | Q04683 | |
| mRNA序列 | NM_001716 | NM_007551 | |
| 蛋白序列 | NP_001707 | NP_031577 | |
| 基因位置 |
Chr 11: 118.75 – 118.77 Mb |
Chr 9: 44.51 – 44.56 Mb | |
| PubMed查询 | [1] | [2] | |
C-X-C趋化因子受体5（英語：C-X-C chemokine receptor type 5，CXC-R5）也被称为CD185（分化簇185）或伯基特淋巴瘤受体1（英語：Burkitt lymphoma receptor 1，BLR1）是一种G蛋白偶联的七跨膜受体，属于CXC趋化因子受体家族，其配体为趋化因子CXCL13（也被称为BLC）。在人类中，CXC-R5蛋白质由 CXCR5 基因编码[1]。
组织分布与功能
BLR1 / CXCR5 基因特异性表达于伯基特淋巴瘤以及其它淋巴组织，比如淋巴结和脾脏中的淋巴滤泡。该基因对B细胞的迁移起到重要作用[2]。
临床意义
T细胞会表达CD4+CXCR5+以对抗结核杆菌（Mtb）感染[3]。
参考文献
- ^ Dobner T, Wolf I, Emrich T, Lipp M. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. Eur. J. Immunol. November 1992, 22 (11): 2795–9. PMID 1425907. doi:10.1002/eji.1830221107.
- ^ Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 1996, 87 (6): 1037–47. PMID 8978608. doi:10.1016/S0092-8674(00)81798-5.
- ^ Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA. CXCR5+ T helper cells mediate protective immunity against tuberculosis. J. Clin. Invest. January 2013. PMC 3561804
. PMID 23281399. doi:10.1172/JCI65728.
延伸阅读
- Lipp M, Müller G. Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking.. Verhandlungen der Deutschen Gesellschaft für Pathologie. 2006, 87: 90–101. PMID 16888899.
- Barella L, Loetscher M, Tobler A; et al. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation.. Biochem. J. 1995, 309 (3): 773–9. PMC 1135699 . PMID 7639692.
- Legler DF, Loetscher M, Roos RS; et al. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5.. J. Exp. Med. 1998, 187 (4): 655–60. PMC 2212150 . PMID 9463416. doi:10.1084/jem.187.4.655.
- Gunn MD, Ngo VN, Ansel KM; et al. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1.. Nature. 1998, 391 (6669): 799–803. PMID 9486651. doi:10.1038/35876.
- Müller G, Lipp M. Signal transduction by the chemokine receptor CXCR5: structural requirements for G protein activation analyzed by chimeric CXCR1/CXCR5 molecules.. Biol. Chem. 2002, 382 (9): 1387–97. PMID 11688722. doi:10.1515/BC.2001.171.
- Schaerli P, Loetscher P, Moser B. Cutting edge: induction of follicular homing precedes effector Th cell development.. J. Immunol. 2002, 167 (11): 6082–6. PMID 11714765. doi:10.4049/jimmunol.167.11.6082.
- Kim CH, Johnston B, Butcher EC. Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.. Blood. 2002, 100 (1): 11–6. PMID 12070001. doi:10.1182/blood-2001-12-0196.
- Carlsen HS, Baekkevold ES, Johansen FE; et al. B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue.. Gut. 2002, 51 (3): 364–71. PMC 1773345 . PMID 12171958. doi:10.1136/gut.51.3.364.
- Battle TE, Yen A. Ectopic expression of CXCR5/BLR1 accelerates retinoic acid- and vitamin D(3)-induced monocytic differentiation of U937 cells.. Exp. Biol. Med. (Maywood). 2002, 227 (9): 753–62. PMID 12324654.
- Lisignoli G, Toneguzzi S, Piacentini A; et al. Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release.. J. Cell. Physiol. 2003, 194 (1): 71–9. PMID 12447991. doi:10.1002/jcp.10188.
- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Chan CC, Shen D, Hackett JJ; et al. Expression of chemokine receptors, CXCR4 and CXCR5, and chemokines, BLC and SDF-1, in the eyes of patients with primary intraocular lymphoma.. Ophthalmology. 2003, 110 (2): 421–6. PMID 12578791. doi:10.1016/S0161-6420(02)01737-2.
- Flynn G, Maru S, Loughlin J; et al. Regulation of chemokine receptor expression in human microglia and astrocytes.. J. Neuroimmunol. 2003, 136 (1-2): 84–93. PMID 12620646. doi:10.1016/S0165-5728(03)00009-2.
- Lisignoli G, Piacentini A, Toneguzzi S; et al. Age-associated changes in functional response to CXCR3 and CXCR5 chemokine receptors in human osteoblasts.. Biogerontology. 2004, 4 (5): 309–17. PMID 14618028. doi:10.1023/A:1026203502385.
- Aust G, Sittig D, Becherer L; et al. The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases.. Eur. J. Endocrinol. 2004, 150 (2): 225–34. PMID 14763921. doi:10.1530/eje.0.1500225.
- Howard OM, Dong HF, Su SB; et al. Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.. Blood. 2005, 105 (11): 4207–14. PMC 1895027 . PMID 15713799. doi:10.1182/blood-2004-07-2697.
- Steinmetz OM, Panzer U, Kneissler U; et al. BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection.. Kidney Int. 2005, 67 (4): 1616–21. PMID 15780119. doi:10.1111/j.1523-1755.2005.00244.x.
- Hu C, Xiong J, Zhang L; et al. PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19+CD34+ B cells from patients with B cell lineage acute and chronic lymphocytic leukemia.. Cell. Mol. Immunol. 2006, 1 (4): 280–94. PMID 16225771.