訊息確認顆粒RNA （Signal recognition particle RNA，簡稱SRP RNA ，又稱7SL RNA ）是生物細胞信號識別顆粒 中的RNA ，在三域 生物中皆有，訊息確認顆粒（SRP）由RNA與蛋白質組成，可與核糖體 轉譯 中多肽上的信號肽 結合，暫停轉譯，並與細胞內質網 （真核生物）或細胞膜 （原核生物）的訊息確認顆粒受體 [ 3] [ 4] 三磷酸鳥苷 （GTP）分子的水解，促使SRP自訊息確認顆粒受體與核糖體脫離，使核糖體繼續多肽的轉譯[ 5] [ 6]
真核生物的SRP由長約300nt 的7SL RNA和6個蛋白質（SRP9、SRP14、SRP19、SRP54、SRP68與SRP72）組成，古菌 的SRP由7SL RNA和2個蛋白質組成[ 7] 真細菌 的SRP則由4.5S RNA和Fth蛋白組成[ 8] [ 9] tRNA 與5S 核糖體RNA 一樣是由RNA聚合酶III 轉錄 [ 10]
除組成SRP之外，有研究發現許多反轉錄病毒 顆粒中含有未與SRP蛋白結合的SRP RNA等宿主細胞的RNA，惟其功能尚不明[ 6] 成纖維細胞 與癌細胞互動後釋放的外排體 中[ 11] 紅血球 細胞中發現未與SRP蛋白結合的SRP RNA[ 12]
人類基因組 中占比超過10%、最常見的短散在核元件 （SINE）Alu元件 可能是自SRP RNA中間一段序列刪除後衍生而來[ 13]
枯草桿菌 的SRP RNA
^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000276168 - Ensembl , May 2017^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Ulbrandt ND, Newitt JA, Bernstein HD. The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins. Cell. 1997, 88 (2): 187–196. PMID 9008159 doi:10.1016/S0092-8674(00)81839-5 ^ Zwieb C, Eichler J. Getting on target: the archaeal signal recognition particle . Archaea. 2002, 1 (1): 27–34. PMC 2685543 PMID 15803656 doi:10.1155/2002/729649 ^ Shan SO, Walter P. Co-translational protein targeting by the signal recognition particle. FEBS Letters. February 2005, 579 (4): 921–926. PMID 15680975 doi:10.1016/j.febslet.2004.11.049 ^ 6.0 6.1 Telesnitsky A, Wolin SL. The Host RNAs in Retroviral Particles. . Viruses. 2016, 8 (8). PMC 4997597 PMID 27548206 doi:10.3390/v8080235 ^ Rosenblad MA, Larsen N, Samuelsson T, Zwieb C. Kinship in the SRP RNA family. RNA Biology. 2009, 6 (5): 508–516. PMID 19838050 doi:10.4161/rna.6.5.9753 ^ Regalia M, Rosenblad MA, Samuelsson T. Prediction of signal recognition particle RNA genes . Nucleic Acids Research. 2002, 30 (15): 3368–3377. PMC 137091 PMID 12140321 doi:10.1093/nar/gkf468 ^ Bishop JM, Levinson WE, Sullivan D, Fanshier L, Quintrell N, Jackson J. The low molecular weight RNAs of Rous sarcoma virus. II. The 7 S RNA. Virology. 1970, 42 (4): 927–937. PMID 4321311 doi:10.1016/0042-6822(70)90341-7 ^ Dieci G, Fiorino G, Castelnuovo M, Teichmann M, Pagano A. The expanding RNA polymerase III transcriptome. . Trends in Genetics. 2007, 23 (12): 614–622. PMID 17977614 doi:10.1016/j.tig.2007.09.001 hdl:11381/1706964 ^ Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoon T, Kim BC; et al. Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. . Cell. 2017, 170 (2): 352–366.e13. PMC 6611169 PMID 28709002 doi:10.1016/j.cell.2017.06.031 ^ Talhouarne GJS, Gall JG. 7SL RNA in vertebrate red blood cells. . RNA. 2018, 24 (7): 908–914. PMC 6004055 PMID 29686135 doi:10.1261/rna.065474.117 ^ Ullu E, Tschudi C. Alu sequences are processed 7SL RNA genes. Nature. 1984, 312 (5990): 171–172. PMID 6209580 doi:10.1038/312171a0
. PMID 15803656. doi:10.1155/2002/729649.
