CD61

CD61
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4O02、​1JV2、​1KUP、​1KUZ、​1L5G、​1M1X、​1M8O、​1MIZ、​1MK7、​1MK9、​1S4X、​1TYE、​1U8C、​2K9J、​2KNC、​2KV9、​2L1C、​2L91、​2LJD、​2LJE、​2LJF、​2MTP、​2Q6W、​2RMZ、​2RN0、​2VC2、​2VDK、​2VDL、​2VDM、​2VDN、​2VDP、​2VDQ、​2VDR、​3FCS、​3FCU、​3IJE、​3NID、​3NIF、​3NIG、​3T3M、​3T3P、​3ZDX、​3ZDY、​3ZDZ、​3ZE0、​3ZE1、​3ZE2、​4CAK、​4G1E、​4G1M、​4MMX、​4MMY、​4MMZ、​5HDB、​4Z7Q、​4Z7O、​4Z7N
识别号
别名	ITGB3；, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2
外部ID	OMIM：173470 MGI：96612 HomoloGene：55444 GeneCards：ITGB3
相关疾病
血小板无力症、​platelet-type bleeding disorder 16
为以下药物的标靶
cilengitide、​依非巴特、​tirofiban hydrochloride hydrate
基因位置（人类） 染色体 17号染色体 基因座 17q21.32 起始 47,253,827 bp 终止 47,313,743 bp
基因位置（小鼠） 染色体 小鼠11号染色体 基因座 11 E1|11 67.84 cM 起始 104,498,826 bp 终止 104,561,302 bp
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • vascular endothelial growth factor receptor 2 binding • fibronectin binding • virus receptor activity • extracellular matrix binding • protein disulfide isomerase activity • 蛋白酶结合 • platelet-derived growth factor receptor binding • 血浆蛋白结合 • 相同蛋白质结合 • 酶结合 • cell adhesion molecule binding • neuregulin binding • coreceptor activity • fibroblast growth factor binding • insulin-like growth factor I binding • C-X3-C chemokine binding • integrin binding • fibrinogen binding 细胞组分 • integral component of membrane • cell projection • alphav-beta3 integrin-vitronectin complex • 膜 • 粘着斑 • 黑色素体 • receptor complex • 细胞膜 • integral component of plasma membrane • ruffle membrane • cell surface • 细胞连接 • integrin complex • platelet alpha granule membrane • integrin alphav-beta3 complex • 外排体 • lamellipodium membrane • 细胞核 • microvillus membrane • filopodium membrane • alphav-beta3 integrin-IGF-1-IGF1R complex • alphav-beta3 integrin-PKCalpha complex • alphav-beta3 integrin-HMGB1 complex • glutamatergic synapse • 突触 生物学过程 • negative regulation of lipoprotein metabolic process • apolipoprotein A-I-mediated signaling pathway • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of protein phosphorylation • regulation of cell migration • negative chemotaxis • positive regulation of endothelial cell proliferation • tube development • heterotypic cell-cell adhesion • angiogenesis involved in wound healing • 伤口愈合 • platelet degranulation • 凝血 • extracellular matrix organization • smooth muscle cell migration • positive regulation of endothelial cell migration • 增殖 • cell-substrate adhesion • vascular endothelial growth factor receptor signaling pathway • 细胞粘附 • positive regulation of peptidyl-tyrosine phosphorylation • mesodermal cell differentiation • cell-substrate junction assembly • integrin-mediated signaling pathway • negative regulation of lipid storage • substrate adhesion-dependent cell spreading • negative regulation of lipid transport • cell-matrix adhesion • viral process • regulation of bone resorption • platelet aggregation • 细胞迁移 • negative regulation of macrophage derived foam cell differentiation • activation of protein kinase activity • leukocyte migration • cell adhesion mediated by integrin • platelet activation • apoptotic cell clearance • regulation of postsynaptic neurotransmitter receptor internalization • regulation of protein localization • regulation of serotonin uptake Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3690	16416
Ensembl	ENSG00000259207	ENSMUSG00000020689
UniProt	P05106	O54890
mRNA​序列	NM_000212	NM_016780
蛋白序列	NP_000203	NP_058060
基因位置​（UCSC）	Chr 17: 47.25 – 47.31 Mb	Chr 11: 104.5 – 104.56 Mb
PubMed​查找
维基数据
查看/编辑人类 查看/编辑小鼠

整联蛋白β-3（Integrin β3）或 CD61（Cluster of differentiation 61）是一种蛋白质 ，在人类基因组中由 ITGB3 基因编码。 CD61 是一种在血小板上表达的分化簇。

进一步阅读

• Bray PF. Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.. Thromb. Haemost. 1995, 72 (4): 492–502. PMID 7878622. 
• Bennett JS. Platelet-fibrinogen interactions.. Ann. N. Y. Acad. Sci. 2001, 936: 340–54. Bibcode:2001NYASA.936..340B. PMID 11460491. doi:10.1111/j.1749-6632.2001.tb03521.x. 
• Sajid M, Stouffer GA. The role of alpha(v)beta3 integrins in vascular healing.. Thromb. Haemost. 2002, 87 (2): 187–93. PMID 11858476. 
• Quinn MJ, Byzova TV, Qin J, et al. Integrin alphaIIbbeta3 and its antagonism.. Arterioscler. Thromb. Vasc. Biol. 2004, 23 (6): 945–52. PMID 12637342. doi:10.1161/01.ATV.0000066686.46338.F1. 
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P. The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.. Italian Heart Journal. 2003, 4 (1): 17–22. PMID 12690916. 
• Smith FB, Connor JM, Lee AJ, et al. Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.. Thromb. Res. 2004, 112 (4): 209–16. PMID 14987913. doi:10.1016/j.thromres.2003.11.010. 
• Fullard JF. The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.. Curr. Pharm. Des. 2004, 10 (14): 1567–76. PMID 15134555. doi:10.2174/1381612043384682. 
• Cacciari B, Spalluto G. Non peptidic alphavbeta3 antagonists: recent developments.. Curr. Med. Chem. 2005, 12 (1): 51–70. PMID 15638730. doi:10.2174/0929867053363522. 
• Watson SP, Auger JM, McCarty OJ, Pearce AC. GPVI and integrin alphaIIb beta3 signaling in platelets.. J. Thromb. Haemost. 2005, 3 (8): 1752–62. PMID 16102042. doi:10.1111/j.1538-7836.2005.01429.x. 
• Bennett JS. Structure and function of the platelet integrin alphaIIbbeta3.. J. Clin. Invest. 2006, 115 (12): 3363–9. PMC 1297263 . PMID 16322781. doi:10.1172/JCI26989. 

外部链接

• 医学主题词表（MeSH）：CD61+Antigens
• ITGB3 信息的链接在 单元的移徙网关
• Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser.