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ABT-418

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ABT-418
識別資訊
  • 3-Methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole
CAS號147402-53-7  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C9H14N2O
摩爾質量166.22
3D模型(JSmol英語JSmol
  • CC1=NOC(=C1)[C@@H]2CCCN2C
  • InChI=1S/C9H14N2O/c1-7-6-9(12-10-7)8-4-3-5-11(8)2/h6,8H,3-5H2,1-2H3/t8-/m0/s1 checkY
  • Key:ILLGYRJAYAAAEW-QMMMGPOBSA-N checkY

ABT-418是一種有機化合物,化學式為C9H14N2O,由美國雅培開發,可用作益智藥抗焦慮藥[1][2][3][4][5]

參考文獻

  1. ^ Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 310–318 [2023-11-09]. PMID 7518514. (原始內容存檔於2005-05-07). 
  2. ^ Decker MW, Brioni JD, Sullivan JP, Buckley MJ, Radek RJ, Raszkiewicz JL, et al. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization. The Journal of Pharmacology and Experimental Therapeutics. July 1994, 270 (1): 319–328 [2023-11-09]. PMID 7913497. (原始內容存檔於2005-05-07). 
  3. ^ Brioni JD, O'Neill AB, Kim DJ, Buckley MJ, Decker MW, Arneric SP. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. The Journal of Pharmacology and Experimental Therapeutics. October 1994, 271 (1): 353–361 [2023-11-09]. PMID 7965735. (原始內容存檔於2009-09-05). 
  4. ^ Prendergast MA, Terry AV, Jackson WJ, Marsh KC, Decker MW, Arneric SP, Buccafusco JJ. Improvement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic receptor agonist ABT-418. Psychopharmacology. April 1997, 130 (3): 276–284. PMID 9151363. S2CID 34377165. doi:10.1007/s002130050240. 
  5. ^ Dallanoce C, Magrone P, Matera C, Lo Presti L, De Amici M, Riganti L, et al. Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. European Journal of Medicinal Chemistry. December 2010, 45 (12): 5594–5601. PMID 20932609. doi:10.1016/j.ejmech.2010.09.009. 

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