跳至內容

周期蛋白A1

維基百科,自由的百科全書
Cyclin A1
周期素A1
標識
代號 CCNA1
擴展標識 遺傳學604036 鼠基因108042 同源基因31203 ChEMBL: 3609 GeneCards: CCNA1 Gene
RNA表達模式
更多表達數據
直系同源體
物種 人類 小鼠
Entrez 8900 12427
Ensembl ENSG00000133101 ENSMUSG00000027793
UniProt P78396 Q61456
mRNA序列 NM_001111045 NM_007628
蛋白序列 NP_001104515 NP_031654
基因位置 Chr 13:
37.01 – 37.02 Mb
Chr 3:
55.05 – 55.06 Mb
PubMed查詢 [1] [2]

周期蛋白A1(英語:Cyclin-A1,或譯為周期素A1)是一個由人類基因 CCNA1 編碼的蛋白質[1]

該基因編碼的蛋白質屬於高度保守的周期蛋白家族,該家族成員的顯著特徵是貫穿細胞周期,其蛋白質豐度周期性地急劇改變。周期蛋白作為CDK(周期蛋白依賴性激酶)的調節因子。不同的周期蛋白表現出各自獨特的表達及降解特性,這有助於每個有絲分裂事件在時間上的協調性。周期蛋白A1表達於睾丸、大腦以及一些嚴重的白血病細胞系中,現任為其主要功能是控制減數分裂。該周期蛋白與Cdk1Cdk2兩種激酶相結合,但這兩種激酶活性完全不相同,前者激酶活性表現於G2期,而後者激酶活性表現於S期,因此在細胞周期中調控了不同的功能。現發現這種周期蛋白可結合到重要的細胞周期調節物上,後者如:Rb家族蛋白、轉錄因子E2F1以及CDK抑制蛋白中的Kip/Cip家族[2]

相互作用

周期蛋白A1能與E2F1[3]CDC20[4]視網膜母細胞瘤蛋白[3]周期蛋白依賴性激酶2英語Cyclin-dependent kinase 2[1][5][6][7]GPS2英語GPS2 (gene)[8] MYBL2[6]GNB2L1[8]發生相互作用

參考文獻

  1. ^ 1.0 1.1 Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194. 
  2. ^ Entrez Gene: CCNA1 cyclin A1. 
  3. ^ 3.0 3.1 Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032可免費查閱. PMID 10022926. 
  4. ^ Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. ISSN 0006-291X. PMID 10679238. doi:10.1006/bbrc.2000.2167. 
  5. ^ Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. A distinct cyclin A is expressed in germ cells in the mouse. Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853. 
  6. ^ 6.0 6.1 Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood (United States). April 2001, 97 (7): 2091–7. ISSN 0006-4971. PMID 11264176. doi:10.1182/blood.V97.7.2091. 
  7. ^ Brown, N R; Noble M E, Endicott J A, Johnson L N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. ISSN 1465-7392. PMID 10559988. doi:10.1038/15674. 
  8. ^ 8.0 8.1 Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. ISSN 0021-9258. PMID 15159402. doi:10.1074/jbc.M401708200. 

延伸閱讀