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SR-16435

維基百科,自由的百科全書
SR-16435
識別資訊
  • 1-[1-(9-bicyclo[3.3.1]nonanyl)piperidin-4-yl]-3H-indol-2-one
CAS號857262-16-9
PubChem CID
化學資訊
化學式C22H30N2O
摩爾質量338.50 g·mol−1
3D模型(JSmol英語JSmol
  • C1CC2CCCC(C1)C2N3CCC(CC3)N4C(=O)CC5=CC=CC=C54
  • InChI=1S/C22H30N2O/c25-21-15-18-5-1-2-10-20(18)24(21)19-11-13-23(14-12-19)22-16-6-3-7-17(22)9-4-8-16/h1-2,5,10,16-17,19,22H,3-4,6-9,11-15H2
  • Key:XVFXJQGBDPFCRF-UHFFFAOYSA-N

SR-16435是一種含氮有機化合物,化學式C22H30N2O,能作為μ-阿片受體痛敏素受體部分激動劑[1][2][3]

參考文獻

  1. ^ Khroyan TV, Zaveri NT, Polgar WE, Orduna J, Olsen C, Jiang F, Toll L. SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice. The Journal of Pharmacology and Experimental Therapeutics. February 2007, 320 (2): 934–43. PMID 17132815. S2CID 2920534. doi:10.1124/jpet.106.111997. 
  2. ^ Spagnolo B, Calo G, Polgar WE, Jiang F, Olsen CM, Berzetei-Gurske I, et al. Activities of mixed NOP and mu-opioid receptor ligands. British Journal of Pharmacology. February 2008, 153 (3): 609–19. PMC 2241792可免費查閱. PMID 18059322. doi:10.1038/sj.bjp.0707598. 
  3. ^ Sukhtankar DD, Zaveri NT, Husbands SM, Ko MC. Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain. The Journal of Pharmacology and Experimental Therapeutics. July 2013, 346 (1): 11–22. PMC 3684842可免費查閱. PMID 23652222. doi:10.1124/jpet.113.203984. 

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