痛覺過敏
痛覺過敏是一種對痛過度敏感的異常狀態，原因可能是傷害感受器或末梢神經受損，其中起到關鍵作用的化學物質為前列腺素E和F[1]。鴨嘴獸毒[2]、長期服用鴉片類藥物[3]都會造成痛覺過敏。依照痛感發生部位的不同，它可分為原發性痛覺過敏和繼發性痛覺過敏兩種。
和神經性疼痛、觸模痛等神經障礙引發的疼痛一樣，痛覺過敏可以通過SSRI、三環抗抑鬱藥[4][5]、非甾體類抗炎藥[6]、糖皮質激素[7]、加巴噴丁[8]、普瑞巴林[9]、NMDA受體拮抗劑[10][11][12] 來治療。換用非典型鴉片類藥物如曲馬朵也有利於減緩病情[13]。
參考文獻
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