甲狀腺激素α受體
甲狀腺激素α受體(THR-α,TR-α),也稱:核受體家族1, A組, 成員1 (NR1A1),是一類核受體蛋白,在人類中由THR-α基因編碼。[7][8][9]
功能
該基因編碼的蛋白質為三碘甲腺原胺酸的核激素受體。它是甲狀腺激素多種受體之一,已被證明可以調節甲狀腺激素的生物活性, 小鼠敲除實驗表明不同的受體雖然具有一定程度的冗餘,但可能介導甲狀腺激素的不同功能。[7]
病理學作用
THRA基因突變可能導致甲狀腺功能減退症, 一種先天性甲狀腺機能低下症亞型。
基因相互作用
甲狀腺激素受體 α 已被證明與以下存在基因相互作用:
參考文獻
- ^ 與甲状腺激素α受体相關的疾病;在維基數據上查看/編輯參考.
- ^ 對thyroid hormone receptor alpha起作用的藥物;在維基數據上查看/編輯參考.
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