STAT2

Signal transducer and activator of transcription 2, 113kDa
信号转导及转录激活蛋白2，113千道尔顿
Signal transducer and activator of transcription 2, 113kDa; 信号转导及转录激活蛋白2，113千道尔顿
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2KA4
标识
代号	STAT2; ISGF-3; P113; STAT113
扩展标识	遗传学：600556 鼠基因：103039 同源基因：3952 GeneCards: STAT2 Gene
基因本体论描述
分子功能	· DNA binding; · sequence-specific DNA binding transcription factor activity; · signal transducer activity; · calcium ion binding; · protein binding;
细胞成分	· nucleoplasm; · cytoplasm; · cytosol; · plasma membrane;
生物过程	· transcription, DNA-dependent; · regulation of transcription from RNA polymerase II promoter; · JAK-STAT cascade; · virus-host interaction; · cytokine-mediated signaling pathway; · defense response to virus; · type I interferon-mediated signaling pathway; · regulation of type I interferon-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	6773
Ensembl	ENSG00000170581
UniProt	P52630
mRNA序列	NM_005419
蛋白序列	NP_005410
基因位置	Chr 12:; 56.74 – 56.75 Mb
PubMed查询	[1]
	查; 论; 编;

信号转导及转录激活蛋白2（英语：Signal transducer and activator of transcription 2）是一种由人类基因STAT2 所表达的蛋白质^[1]^[2]。

相互作用

STAT2能与MED14^[3]、CREB结合蛋白（英语：CREB-binding protein）^[4]、SMARCA4^[5]、STAT1^[6]^[7]^[8]、IFNAR2^[9]^[10] IFNAR1^[9]^[11]^[12]和ISGF3G^[13]^[14]相互作用。

参考文献

^ Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE Jr. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. Nucleic Acids Res. Apr 1995, 23 (3): 459–63. PMC 306697 . PMID 7885841. doi:10.1093/nar/23.3.459.
^ Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa.
^ Lau, Joe F; Nusinzon Inna, Burakov Darya, Freedman Leonard P, Horvath Curt M. Role of metazoan mediator proteins in interferon-responsive transcription. Mol. Cell. Biol. (United States). Jan 2003, 23 (2): 620–8. ISSN 0270-7306. PMC 151539 . PMID 12509459. doi:10.1128/MCB.23.2.620-628.2003.
^ Bhattacharya, S; Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston D M. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (ENGLAND). Sep 1996, 383 (6598): 344–7. ISSN 0028-0836. PMID 8848048. doi:10.1038/383344a0.
^ Huang, Mei; Qian Feng, Hu Yuanyu, Ang Chengeng, Li Zhong, Wen Zilong. Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat. Cell Biol. (England). Oct 2002, 4 (10): 774–81. ISSN 1465-7392. PMID 12244326. doi:10.1038/ncb855.
^ Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. (UNITED STATES). Mar 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790.
^ Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J. Biol. Chem. (UNITED STATES). Aug 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059.
^ Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J. Biol. Chem. (United States). Aug 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200.
^ ^9.0 ^9.1 Li, X; Leung S, Kerr I M, Stark G R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. (UNITED STATES). Apr 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052 . PMID 9121453.
^ Nguyen, Vinh-Phúc; Saleh Abu Z M, Arch Allison E, Yan Hai, Piazza Flavia, Kim John, Krolewski John J. Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. J. Biol. Chem. (United States). Mar 2002, 277 (12): 9713–21. ISSN 0021-9258. PMID 11786546. doi:10.1074/jbc.M111161200.
^ Uddin, S; Chamdin A, Platanias L C. Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. J. Biol. Chem. (UNITED STATES). Oct 1995, 270 (42): 24627–30. ISSN 0021-9258. PMID 7559568. doi:10.1074/jbc.270.42.24627.
^ Yan, H; Krishnan K, Greenlund A C, Gupta S, Lim J T, Schreiber R D, Schindler C W, Krolewski J J. Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. (ENGLAND). Mar 1996, 15 (5): 1064–74. ISSN 0261-4189. PMC 450004 . PMID 8605876.
^ Horvath, C M; Stark G R, Kerr I M, Darnell J E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. (UNITED STATES). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699 . PMID 8943351.
^ Martinez-Moczygemba, M; Gutch M J, French D L, Reich N C. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J. Biol. Chem. (UNITED STATES). Aug 1997, 272 (32): 20070–6. ISSN 0021-9258. PMID 9242679. doi:10.1074/jbc.272.32.20070.

延伸阅读

Cebulla CM, Miller DM, Sedmak DD. Viral inhibition of interferon signal transduction.. Intervirology. 2000, 42 (5–6): 325–30. PMID 10702714. doi:10.1159/000053968.
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene. 2002, 285 (1–2): 1–24. PMID 12039028. doi:10.1016/S0378-1119(02)00398-0.
Fu XY, Schindler C, Improta T; et al. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (16): 7840–3. PMC 49807 . PMID 1502204. doi:10.1073/pnas.89.16.7840.
Uddin S, Chamdin A, Platanias LC. Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. J. Biol. Chem. 1995, 270 (42): 24627–30. PMID 7559568. doi:10.1074/jbc.270.42.24627.
Marrero MB, Schieffer B, Paxton WG; et al. Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature. 1995, 375 (6528): 247–50. PMID 7746328. doi:10.1038/375247a0.
Sugiyama T, Nishio Y, Kishimoto T, Akira S. Identification of alternative splicing form of Stat2. FEBS Lett. 1996, 381 (3): 191–4. PMID 8601453. doi:10.1016/0014-5793(96)00121-4.
Yan H, Krishnan K, Greenlund AC; et al. Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 1996, 15 (5): 1064–74. PMC 450004 . PMID 8605876.
Gupta S, Yan H, Wong LH; et al. The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals. EMBO J. 1996, 15 (5): 1075–84. PMC 450005 . PMID 8605877.
Li X, Leung S, Qureshi S; et al. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. 1996, 271 (10): 5790–4. PMID 8621447. doi:10.1074/jbc.271.10.5790.
Bhattacharya S, Eckner R, Grossman S; et al. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature. 1996, 383 (6598): 344–7. PMID 8848048. doi:10.1038/383344a0.
Horvath CM, Stark GR, Kerr IM, Darnell JE. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. 1997, 16 (12): 6957–64. PMC 231699 . PMID 8943351.
Bluyssen HA, Levy DE. Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA. J. Biol. Chem. 1997, 272 (7): 4600–5. PMID 9020188. doi:10.1074/jbc.272.7.4600.
Li X, Leung S, Kerr IM, Stark GR. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. 1997, 17 (4): 2048–56. PMC 232052 . PMID 9121453.
Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J. Biol. Chem. 1997, 272 (32): 20070–6. PMID 9242679. doi:10.1074/jbc.272.32.20070.
Mowen K, David M. Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J. Biol. Chem. 1998, 273 (46): 30073–6. PMID 9804758. doi:10.1074/jbc.273.46.30073.
Dumler I, Kopmann A, Wagner K; et al. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J. Biol. Chem. 1999, 274 (34): 24059–65. PMID 10446176. doi:10.1074/jbc.274.34.24059.
Paulson M, Pisharody S, Pan L; et al. Stat protein transactivation domains recruit p300/CBP through widely divergent sequences. J. Biol. Chem. 1999, 274 (36): 25343–9. PMID 10464260. doi:10.1074/jbc.274.36.25343.
Gupta S, Jiang M, Pernis AB. IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. J. Immunol. 1999, 163 (7): 3834–41. PMID 10490982.
Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A; et al. The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J. 1999, 13 (13): 1699–710. PMID 10506573.

外部链接

STAT2引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。

[pmid7885841-1] Yan R, Qureshi S, Zhong Z, Wen Z, Darnell JE Jr. The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2. Nucleic Acids Res. Apr 1995, 23 (3): 459–63. PMC 306697 . PMID 7885841. doi:10.1093/nar/23.3.459.

[entrez-2] Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa.

[pmid12509459-3] Lau, Joe F; Nusinzon Inna, Burakov Darya, Freedman Leonard P, Horvath Curt M. Role of metazoan mediator proteins in interferon-responsive transcription. Mol. Cell. Biol. (United States). Jan 2003, 23 (2): 620–8. ISSN 0270-7306. PMC 151539 . PMID 12509459. doi:10.1128/MCB.23.2.620-628.2003.

[pmid8848048-4] Bhattacharya, S; Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston D M. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha. Nature (ENGLAND). Sep 1996, 383 (6598): 344–7. ISSN 0028-0836. PMID 8848048. doi:10.1038/383344a0.

[pmid12244326-5] Huang, Mei; Qian Feng, Hu Yuanyu, Ang Chengeng, Li Zhong, Wen Zilong. Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes. Nat. Cell Biol. (England). Oct 2002, 4 (10): 774–81. ISSN 1465-7392. PMID 12244326. doi:10.1038/ncb855.

[pmid8621447-6] Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. (UNITED STATES). Mar 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790.

[pmid10446176-7] Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J. Biol. Chem. (UNITED STATES). Aug 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059.

[pmid12048190-8] Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J. Biol. Chem. (United States). Aug 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200.

[pmid9121453-9] 9.0 ^9.1 Li, X; Leung S, Kerr I M, Stark G R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. (UNITED STATES). Apr 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052 . PMID 9121453.

[pmid11786546-10] Nguyen, Vinh-Phúc; Saleh Abu Z M, Arch Allison E, Yan Hai, Piazza Flavia, Kim John, Krolewski John J. Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling. J. Biol. Chem. (United States). Mar 2002, 277 (12): 9713–21. ISSN 0021-9258. PMID 11786546. doi:10.1074/jbc.M111161200.

[pmid7559568-11] Uddin, S; Chamdin A, Platanias L C. Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. J. Biol. Chem. (UNITED STATES). Oct 1995, 270 (42): 24627–30. ISSN 0021-9258. PMID 7559568. doi:10.1074/jbc.270.42.24627.

[pmid8605876-12] Yan, H; Krishnan K, Greenlund A C, Gupta S, Lim J T, Schreiber R D, Schindler C W, Krolewski J J. Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. (ENGLAND). Mar 1996, 15 (5): 1064–74. ISSN 0261-4189. PMC 450004 . PMID 8605876.

[pmid8943351-13] Horvath, C M; Stark G R, Kerr I M, Darnell J E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. (UNITED STATES). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699 . PMID 8943351.

[pmid9242679-14] Martinez-Moczygemba, M; Gutch M J, French D L, Reich N C. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J. Biol. Chem. (UNITED STATES). Aug 1997, 272 (32): 20070–6. ISSN 0021-9258. PMID 9242679. doi:10.1074/jbc.272.32.20070.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]