L-苏氨酸3-脱氢酶(英语:L-threonine 3-dehydrogenase,EC 1.1.1.103 (页面存档备份,存于互联网档案馆)),是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应:
- L-苏氨酸 + NAD+ L-2-氨基-3-氧代丁酸 + NADH + H+
上述反应的产物L-2-氨基-3-氧代丁酸在水溶液中能自发转化为氨基丙酮。L-苏氨酸3-脱氢酶主要参与甘氨酸、丝氨酸和苏氨酸的代谢过程。这种酶能与甘氨酸C-乙酰基转移酶(glycine C-acetyltransferase,2.3.1.29 (页面存档备份,存于互联网档案馆))结合成为复合物协同作用,参与苏氨酸的降解过程,该苏氨酸降解途径在原核细胞及真核细胞中都很常见。[1]
参考文献
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- Newman, E.B., Kapoor, V. and Potter, R. Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli.. J. Bacteriol. 1976, 126: 1245–. PMID 7548.
- Epperly, B.R. and Dekker, E.E. L-Threonine dehydrogenase from Escherichia coli. Identification of an active site cysteine residue and metal ion studies.. J. Biol. Chem. 1991, 266: 6086–6092 [2012-08-08]. PMID 2007567. (原始内容存档于2016-03-04).