萘普生铜

萘普生铜
别名	6-甲氧基-a-甲基-2-萘乙酸铜
性质
化学式	C28H26CuO6
摩尔质量	522.05 g·mol−1
外观	绿色晶体
溶解性	溶于甲醇、1,4-二𫫇烷、二甲基亚砜、2,5-二甲基呋喃
相关物质
相关化学品	乙酰水杨酸铜; 布洛芬铜
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

萘普生铜（英语：Copper naproxen）是二价铜与抗炎药萘普生螯合的化学络合物。^[1]萘普生等非甾体抗炎药的铜络合物已被证明比基础药物具有更强的抗炎特性。^[3]^[2]

萘普生铜可以以一水合物的形式存在，并且可以与其他有机分子（例如烟醇、3-甲基吡啶和咖啡因）形成络合物。^[1]^[4]^[5]

制备

萘普生铜通过萘普生钠与二价铜盐（如硫酸铜）的反应来制备。^[1]

${\ce {2C14H13NaO3 + CuSO4 -> C28H26CuO6 + Na2SO4}}$

参考资料

^ ^1.0 ^1.1 ^1.2 ^1.3 Melnı́k, Milan; Macásková, Lubov; Holloway, Clive E; Mrozinski, Jerzy; Kalin’ska, Bozena. Spectral and magnetic properties of copper(II) naproxenates. Inorganica Chimica Acta. March 2000, 299 (2): 284–287 [2023-10-07]. doi:10.1016/S0020-1693(99)00504-6. （原始内容存档于2018-06-22）（英语）.
^ ^2.0 ^2.1 Dimiza, Filitsa; Perdih, Franc; Tangoulis, Vassilis; Turel, Iztok; Kessissoglou, Dimitris P.; Psomas, George. Interaction of copper(II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA- and albumin-binding. Journal of Inorganic Biochemistry. March 2011, 105 (3): 476–489 [2023-10-07]. doi:10.1016/j.jinorgbio.2010.08.013. （原始内容存档于2022-11-17）（英语）.
^ Sorenson, John R.J., 6 Copper Complexes Offer a Physiological Approach to Treatment of Chronic Diseases, Progress in Medicinal Chemistry 26, Elsevier: 437–568, 1989 [2022-04-10], ISBN 978-0-444-81038-0, doi:10.1016/s0079-6468(08)70246-7, （原始内容存档于2019-04-01）（英语）
^ Caglar, Sema; Adiguzel, Ekrem; Sariboga, Bahtiyar; Temel, Ersin; Buyukgungor, Orhan. Mono and dinuclear copper(II) naproxenato complexes containing 3-picoline and 4-picoline: synthesis, structure, properties, catechol oxidase, and antimicrobial activities. Journal of Coordination Chemistry. 2014-02-16, 67 (4): 670–683 [2023-10-07]. ISSN 0095-8972. S2CID 96991445. doi:10.1080/00958972.2014.891198. （原始内容存档于2022-04-11）（英语）.
^ Abuhijleh, A. Latif; Khalaf, Juhienah. Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase – mimetic activities. European Journal of Medicinal Chemistry. September 2010, 45 (9): 3811–3817 [2023-10-07]. PMID 20605277. doi:10.1016/j.ejmech.2010.05.031. （原始内容存档于2023-04-17）（英语）.

[Melnik-1] 1.0 ^1.1 ^1.2 ^1.3 Melnı́k, Milan; Macásková, Lubov; Holloway, Clive E; Mrozinski, Jerzy; Kalin’ska, Bozena. Spectral and magnetic properties of copper(II) naproxenates. Inorganica Chimica Acta. March 2000, 299 (2): 284–287 [2023-10-07]. doi:10.1016/S0020-1693(99)00504-6. （原始内容存档于2018-06-22）（英语）.

[Dimiza-2] 2.0 ^2.1 Dimiza, Filitsa; Perdih, Franc; Tangoulis, Vassilis; Turel, Iztok; Kessissoglou, Dimitris P.; Psomas, George. Interaction of copper(II) with the non-steroidal anti-inflammatory drugs naproxen and diclofenac: Synthesis, structure, DNA- and albumin-binding. Journal of Inorganic Biochemistry. March 2011, 105 (3): 476–489 [2023-10-07]. doi:10.1016/j.jinorgbio.2010.08.013. （原始内容存档于2022-11-17）（英语）.

[3] Sorenson, John R.J., 6 Copper Complexes Offer a Physiological Approach to Treatment of Chronic Diseases, Progress in Medicinal Chemistry 26, Elsevier: 437–568, 1989 [2022-04-10], ISBN 978-0-444-81038-0, doi:10.1016/s0079-6468(08)70246-7, （原始内容存档于2019-04-01）（英语）

[4] Caglar, Sema; Adiguzel, Ekrem; Sariboga, Bahtiyar; Temel, Ersin; Buyukgungor, Orhan. Mono and dinuclear copper(II) naproxenato complexes containing 3-picoline and 4-picoline: synthesis, structure, properties, catechol oxidase, and antimicrobial activities. Journal of Coordination Chemistry. 2014-02-16, 67 (4): 670–683 [2023-10-07]. ISSN 0095-8972. S2CID 96991445. doi:10.1080/00958972.2014.891198. （原始内容存档于2022-04-11）（英语）.

[5] Abuhijleh, A. Latif; Khalaf, Juhienah. Copper (II) complexes of the anti-inflammatory drug naproxen and 3-pyridylmethanol as auxiliary ligand. Characterization, superoxide dismutase and catecholase – mimetic activities. European Journal of Medicinal Chemistry. September 2010, 45 (9): 3811–3817 [2023-10-07]. PMID 20605277. doi:10.1016/j.ejmech.2010.05.031. （原始内容存档于2023-04-17）（英语）.

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