白细胞介素-4

白细胞介素-4
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1BBN、1BCN、1CYL、1HIJ、1HIK、1HZI、1IAR、1ITI、1ITL、1ITM、1RCB、2B8U、2B8X、2B8Y、2B8Z、2B90、2B91、2CYK、2D48、2INT、3BPL、3BPN、3QB7、4YDY、5FHX
识别号
别名	IL4；, Interleukin 4, IL-4
外部ID	MGI：96556 HomoloGene：491 GeneCards：IL4
基因位置（人类）
染色体	5号染色体
终止	132,018,370 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	53,509,496 bp
基因本体
分子功能	• 白细胞介素-4受体结合; • 血浆蛋白结合; • 生长因子活性; • 细胞因子受体结合; • 细胞因子活性;
细胞组分	• 细胞外区域; • 细胞外空间;
生物学过程	• positive regulation of T cell differentiation; • dendritic cell differentiation; • 内皮细胞凋亡过程的负调控; • negative regulation of complement-dependent cytotoxicity; • regulation of phosphorylation; • negative regulation of apoptotic process; • myeloid dendritic cell differentiation; • type 2 immune response; • B cell activation; • positive regulation of interleukin-13 production; • 免疫反应; • B cell differentiation; • T-helper 2 cell cytokine production; • regulation of isotype switching; • negative regulation of transcription, DNA-templated; • negative regulation of epithelial cell migration; • regulation of signaling receptor activity; • cholesterol metabolic process; • positive regulation of B cell proliferation; • positive regulation of T cell proliferation; • T细胞激活; • positive regulation of MHC class II biosynthetic process; • negative regulation of osteoclast differentiation; • positive regulation of transcription, DNA-templated; • positive regulation of transcription by RNA polymerase II; • positive regulation of isotype switching to IgE isotypes; • positive regulation of isotype switching to IgG isotypes; • regulation of immune response; • cytokine-mediated signaling pathway; • positive regulation of gene expression; • positive regulation of macroautophagy; • positive regulation of tyrosine phosphorylation of STAT protein; • activation of Janus kinase activity; • positive regulation of receptor-mediated endocytosis; • positive regulation of cold-induced thermogenesis; • negative regulation of neuroinflammatory response; • positive regulation of amyloid-beta clearance; • neuroinflammatory response; • positive regulation of cellular respiration; • positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	3565
	16189
	ENSG00000113520
	ENSMUSG00000000869
	P05112
	P07750
	NM_000589.4
	NM_021283
	NP_000580; NP_758858; NP_001341919
	NP_067258
	维基数据
查看/编辑人类	查看/编辑小鼠

白细胞介素-4（白介素-4, Interleukin-4, IL-4）是II型辅助T细胞（Th2细胞）分泌的细胞因子。白细胞介素-4的生物作用，包括刺激活化B细胞和T细胞增殖、 CD4+T细胞分化成II型辅助T细胞. 它也在调节体液免疫和适应性免疫中起关键作用。白细胞介素-4诱导B细胞抗体类别转换向IgE，上调第二型主要组织兼容性复合体的产生。这一因子是由M.霍华德、W.保罗和E. 委特塔（Vitetta）在1982共同发现的。四年后人类白细胞介素-4的核苷酸序列中被分离，证实它与一小鼠蛋白B细胞刺激因子-1（BCSF-1）类似^[4].

参看

参考文献

^ ^1.0 ^1.1 ^1.2 GRCm38: Ensembl release 89: ENSMUSG00000000869 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.

外部链接

MeSH|Interleukin+4 （页面存档备份，存于互联网档案馆）

[refGRCm38Ensembl-1] 1.0 ^1.1 ^1.2 GRCm38: Ensembl release 89: ENSMUSG00000000869 - Ensembl, May 2017

[2] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.

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