白細胞介素-4

白細胞介素-4
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1BBN、1BCN、1CYL、1HIJ、1HIK、1HZI、1IAR、1ITI、1ITL、1ITM、1RCB、2B8U、2B8X、2B8Y、2B8Z、2B90、2B91、2CYK、2D48、2INT、3BPL、3BPN、3QB7、4YDY、5FHX
識別號
別名	IL4；, Interleukin 4, IL-4
外部ID	MGI：96556 HomoloGene：491 GeneCards：IL4
基因位置（人類）
染色體	5號染色體
終止	132,018,370 bp
基因位置（小鼠）
染色體	小鼠11號染色體
終止	53,509,496 bp
基因本體
分子功能	• 白細胞介素-4受體結合; • 血漿蛋白結合; • 生長因子活性; • 細胞因子受體結合; • 細胞因子活性;
細胞組分	• 細胞外區域; • 細胞外空間;
生物學過程	• positive regulation of T cell differentiation; • dendritic cell differentiation; • 內皮細胞凋亡過程的負調控; • negative regulation of complement-dependent cytotoxicity; • regulation of phosphorylation; • negative regulation of apoptotic process; • myeloid dendritic cell differentiation; • type 2 immune response; • B cell activation; • positive regulation of interleukin-13 production; • 免疫反應; • B cell differentiation; • T-helper 2 cell cytokine production; • regulation of isotype switching; • negative regulation of transcription, DNA-templated; • negative regulation of epithelial cell migration; • regulation of signaling receptor activity; • cholesterol metabolic process; • positive regulation of B cell proliferation; • positive regulation of T cell proliferation; • T細胞活化; • positive regulation of MHC class II biosynthetic process; • negative regulation of osteoclast differentiation; • positive regulation of transcription, DNA-templated; • positive regulation of transcription by RNA polymerase II; • positive regulation of isotype switching to IgE isotypes; • positive regulation of isotype switching to IgG isotypes; • regulation of immune response; • cytokine-mediated signaling pathway; • positive regulation of gene expression; • positive regulation of macroautophagy; • positive regulation of tyrosine phosphorylation of STAT protein; • activation of Janus kinase activity; • positive regulation of receptor-mediated endocytosis; • positive regulation of cold-induced thermogenesis; • negative regulation of neuroinflammatory response; • positive regulation of amyloid-beta clearance; • neuroinflammatory response; • positive regulation of cellular respiration; • positive regulation of ATP biosynthetic process;
	Sources:Amigo / QuickGO
直系同源
	3565
	16189
	ENSG00000113520
	ENSMUSG00000000869
	P05112
	P07750
	NM_000589.4
	NM_021283
	NP_000580; NP_758858; NP_001341919
	NP_067258
	維基數據
檢視/編輯人類	檢視/編輯小鼠

白細胞介素-4（白介素-4, Interleukin-4, IL-4）是II型輔助T細胞（Th2細胞）分泌的細胞因子。白細胞介素-4的生物作用，包括刺激活化B細胞和T細胞增殖、 CD4+T細胞分化成II型輔助T細胞. 它也在調節體液免疫和適應性免疫中起關鍵作用。白細胞介素-4誘導B細胞抗體類別轉換向IgE，上調第二型主要組織兼容性複合體的產生。這一因子是由M.霍華德、W.保羅和E. 委特塔（Vitetta）在1982共同發現的。四年後人類白細胞介素-4的核苷酸序列中被分離，證實它與一小鼠蛋白B細胞刺激因子-1（BCSF-1）類似^[4].

參看

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCm38: Ensembl release 89: ENSMUSG00000000869 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.

外部連結

MeSH|Interleukin+4 （頁面存檔備份，存於網際網路檔案館）

[refGRCm38Ensembl-1] 1.0 ^1.1 ^1.2 GRCm38: Ensembl release 89: ENSMUSG00000000869 - Ensembl, May 2017

[2] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Yokota et al., Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences USA, 1986, Volume 83, pages 5894-5898.

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