RAD51

RAD51
	Rad51结构图。来源：PDB 1SZP
识别
符号	RAD51
替换符号	RAD51A, RECA
Entrez	5888
HUGO	9817
OMIM	179617
PDB	1SZP
RefSeq	NM_002875
UniProt	Q06609
其他数据
基因座	15号 q15.1

RAD51
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1N0W、1B22
识别号
别名	RAD51；, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase
外部ID	OMIM：179617 MGI：97890 HomoloGene：2155 GeneCards：RAD51
相关疾病
	Fanconi anemia complementation group R
基因位置（人类）
染色体	15号染色体
终止	40,732,340 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• 核苷酸结合; • DNA结合; • ATP-dependent activity, acting on DNA; • DNA strand exchange activity; • DNA polymerase binding; • protein C-terminus binding; • 血浆蛋白结合; • four-way junction DNA binding; • 相同蛋白质结合; • endodeoxyribonuclease activity; • ATP结合; • single-stranded DNA binding; • double-stranded DNA binding; • single-stranded DNA helicase activity; • chromatin binding; • 酶结合;
细胞组分	• 细胞质; • site of double-strand break; • PML body; • 细胞骨架; • 核质; • 微管组织中心; • nuclear chromosome; • 线粒体基质; • 核仁; • 线粒体; • 细胞质的核周区域; • 染色质; • 细胞核; • 细胞质基质; • 大分子复合体; • condensed chromosome; • condensed nuclear chromosome; • lateral element; • 染色体;
生物学过程	• strand invasion; • mitotic recombination-dependent replication fork processing; • reciprocal meiotic recombination; • DNA重组; • regulation of double-strand break repair via homologous recombination; • DNA代谢过程; • positive regulation of DNA ligation; • cellular response to camptothecin; • double-strand break repair via homologous recombination; • cellular response to ionizing radiation; • mitotic recombination; • protein homooligomerization; • DNA修复; • DNA unwinding involved in DNA replication; • cellular response to DNA damage stimulus; • interstrand cross-link repair; • DNA recombinase assembly; • negative regulation of G0 to G1 transition; • telomere maintenance via recombination; • telomere maintenance via telomere lengthening; • replication fork processing; • 减数分裂; • chromosome organization involved in meiotic cell cycle;
	Sources:Amigo / QuickGO
直系同源
	5888
	19361
	ENSG00000051180
	无数据
	Q06609
	Q08297
	NM_001164269; NM_001164270; NM_002875; NM_133487
	NM_011234
	NP_001157741; NP_001157742; NP_002866; NP_597994
	NP_035364
	维基数据
查看/编辑人类	查看/编辑小鼠

Rad51是真核生物体内的一种蛋白质，与原核生物的RecA 同源，是一种高度保守的蛋白，从酵母菌到人类之间的变异不大。人类的Rad51含有339个氨基酸，于同源重组中扮演主要角色，参与搜索同源部位与DNA的配对过程。

人类的Rad51的基因位于第15号染色体。包括此基因在内，哺乳类共有七种类似recA的基因，包括Rad51、Rad51L1/B、Rad51L2/C、Rad51L3/D、XRCC2、XRCC3以及DMC1^[6]。

参考文献

^ 與RAD51相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000051180 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ [1] （页面存档备份，存于互联网档案馆） Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004
^ Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)

Galkin,V .E. et al. The Rad51/RadA N-Terminal domain activates nucleoprotein filament ATPase activity. Structure 14, pp. 983-992(2006)

Pellegrini, L. et al. Insights into DNA recombination from the structure of a Rad51-BRCA2 complex. Nature 420,287-293(2002)

外部链接

医学主题词表（MeSH）：RAD51+Protein

[1] 與RAD51相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000051180 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] [1] （页面存档备份，存于互联网档案馆） Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004

[6] Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)

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