RAD51

RAD51
	Rad51結構圖。來源：PDB 1SZP
識別
符號	RAD51
替換符號	RAD51A, RECA
Entrez	5888
HUGO	9817
OMIM	179617
PDB	1SZP
RefSeq	NM_002875
UniProt	Q06609
其他資料
基因座	15號 q15.1

RAD51
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1N0W、1B22
識別號
别名	RAD51；, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase
外部ID	OMIM：179617 MGI：97890 HomoloGene：2155 GeneCards：RAD51
相關疾病
	Fanconi anemia complementation group R
基因位置（人类）
染色体	15號染色體
终止	40,732,340 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本體
分子功能	• 核苷酸結合; • DNA结合; • ATP-dependent activity, acting on DNA; • DNA strand exchange activity; • DNA polymerase binding; • protein C-terminus binding; • 血浆蛋白结合; • four-way junction DNA binding; • 相同蛋白质结合; • endodeoxyribonuclease activity; • ATP結合; • single-stranded DNA binding; • double-stranded DNA binding; • single-stranded DNA helicase activity; • chromatin binding; • 酶结合;
細胞組分	• 細胞質; • site of double-strand break; • PML body; • 细胞骨架; • 核质; • 微管组织中心; • nuclear chromosome; • 线粒体基质; • 核仁; • 線粒體; • 细胞质的核周区域; • 染色质; • 细胞核; • 细胞质基质; • 大分子复合体; • condensed chromosome; • condensed nuclear chromosome; • lateral element; • 染色体;
生物學過程	• strand invasion; • mitotic recombination-dependent replication fork processing; • reciprocal meiotic recombination; • DNA重组; • regulation of double-strand break repair via homologous recombination; • DNA代谢过程; • positive regulation of DNA ligation; • cellular response to camptothecin; • double-strand break repair via homologous recombination; • cellular response to ionizing radiation; • mitotic recombination; • protein homooligomerization; • DNA修復; • DNA unwinding involved in DNA replication; • cellular response to DNA damage stimulus; • interstrand cross-link repair; • DNA recombinase assembly; • negative regulation of G0 to G1 transition; • telomere maintenance via recombination; • telomere maintenance via telomere lengthening; • replication fork processing; • 減數分裂; • chromosome organization involved in meiotic cell cycle;
	Sources:Amigo / QuickGO
直系同源
	5888
	19361
	ENSG00000051180
	无数据
	Q06609
	Q08297
	NM_001164269; NM_001164270; NM_002875; NM_133487
	NM_011234
	NP_001157741; NP_001157742; NP_002866; NP_597994
	NP_035364
	維基數據
檢視/編輯人類	檢視/編輯小鼠

Rad51是真核生物體內的一種蛋白質，与原核生物的RecA 同源，是一种高度保守的蛋白，從酵母菌到人類之間的變異不大。人類的Rad51含有339個氨基酸，於同源重組中扮演主要角色，參與搜尋同源部位與DNA的配對過程。

人類的Rad51的基因位於第15號染色體。包括此基因在內，哺乳類共有七種類似recA的基因，包括Rad51、Rad51L1/B、Rad51L2/C、Rad51L3/D、XRCC2、XRCC3以及DMC1^[6]。

參考文獻

^ 與RAD51相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000051180 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ [1] （页面存档备份，存于互联网档案馆） Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004
^ Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)

Galkin,V .E. et al. The Rad51/RadA N-Terminal domain activates nucleoprotein filament ATPase activity. Structure 14, pp. 983-992(2006)

Pellegrini, L. et al. Insights into DNA recombination from the structure of a Rad51-BRCA2 complex. Nature 420,287-293(2002)

外部連結

醫學主題詞表（MeSH）：RAD51+Protein

[1] 與RAD51相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000051180 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] [1] （页面存档备份，存于互联网档案馆） Conway, A.B., Lynch, T.W., Zhang, Y., Fortin, G.S., Fung, C.W., Symington, L.S., Rice, P.A. Crystal structure of a Rad51 filament. Nat.Struct.Mol.Biol. v11 pp.791-796, 2004

[6] Kawabata,M., Kawabata, T. and Nishibori, M. Role of recA/Rad51 family proteins in mammals. Acta Med.Okayama v59, No.1, pp.1-9(2005)

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