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6-羟基犬尿喹啉酸

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6-羟基犬尿喹啉酸
IUPAC名
4,6-Dihydroxyquinoline-2-carboxylic acid
识别
CAS号 3778-29-8
PubChem 440752
ChemSpider 389622
SMILES
 
  • C1=CC2=C(C=C1O)C(=CC(=N2)C(=O)O)O
InChI
 
  • 1/C10H7NO4/c12-5-1-2-7-6(3-5)9(13)4-8(11-7)10(14)15/h1-4,12H,(H,11,13)(H,14,15)
InChIKey CQUUHDQRJWXDPY-UHFFFAOYAS
性质
化学式 C10H7NO4
摩尔质量 205.17 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

6-羟基犬尿喹啉酸(英语:6-Hydroxykynurenic acid)是一种含氮杂环化合物,化学式为C10H7NO4,为犬尿喹啉酸(一种氨基酸代谢产物)的衍生物,存在于银杏[1],能作为AMPA和NMDA的受体拮抗剂[2]

参考文献

  1. ^ van Beek, Teris A. Chemical analysis of Ginkgo biloba leaves and extracts. Journal of Chromatography A. Chromatographic and Electrophoretic Analysis of Secondary Metabolites of Plants. 2002-08-16, 967 (1): 21–55. ISSN 0021-9673. PMID 12219929. doi:10.1016/S0021-9673(02)00172-3 (英语). 
  2. ^ Weber, Marco; Dietrich, Dirk; Gräsel, Ines; Reuter, Gerhard; Seifert, Gerald; Steinhäuser, Christian. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones: 6-Hydroxykynurenate blocks glutamate receptors. Journal of Neurochemistry. 2001-12-20, 77 (4): 1108–1115. PMID 11359876. S2CID 23178914. doi:10.1046/j.1471-4159.2001.00340.x可免费查阅 (英语). 

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