胱抑素A

血清胱抑素A
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1CYU、1CYV、1DVC、1DVD、1GD3、1GD4、1N9J、1NB3、1NB5、3K9M、3KFQ、3KSE
识别号
别名	CSTA；, AREI, STF1, STFA, Cystatin A, PSS4
外部ID	OMIM：184600 MGI：3644688 HomoloGene：3819 GeneCards：CSTA
相关疾病
	Exfoliative ichthyosis
基因位置（人类）
染色体	3号染色体
终止	122,341,969 bp
基因位置（小鼠）
染色体	小鼠16号染色体
终止	36,038,158 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• peptidase inhibitor activity; • 蛋白酶结合; • protein-macromolecule adaptor activity; • endopeptidase inhibitor activity; • structural molecule activity; • cysteine-type endopeptidase inhibitor activity;
细胞组分	• 细胞质; • 胞内; • cornified envelope; • 细胞外空间; • 细胞核; • 细胞质基质;
生物学过程	• negative regulation of proteolysis; • peptide cross-linking; • negative regulation of peptidase activity; • 细胞粘附; • keratinocyte differentiation; • negative regulation of endopeptidase activity; • 细胞角质化; • cell-cell adhesion;
	Sources:Amigo / QuickGO
直系同源
	1475
	408196
	ENSG00000121552
	ENSMUSG00000094733
	P01040
	Q6IE28
	NM_005213
	NM_001082542
	NP_005204
	NP_001076011
	维基数据
查看/编辑人类	查看/编辑小鼠

胱抑素A是一种在人体中由CSTA基因编码的蛋白质。^[6]^[7]

胱抑素超家族包括含有多个胱抑素样序列的蛋白质。一些成员是活性半胱氨酸蛋白酶抑制剂，而其他成员已经失去或可能从未获得这种抑制活性。超家族中有3个抑制家族，包括1型胱抑素（stefin）、2型胱抑素和激肽原。该基因编码一种stefin，起半胱氨酸蛋白酶抑制剂的作用，与木瓜蛋白酶和组织蛋白酶B、H和L形成紧密复合物。该蛋白是角质形成细胞中角化细胞包膜的前体蛋白之一，在表皮发育和维护。Stefin已被提议作为癌症的预后和诊断工具。^[7]

相互作用

胱抑素A已被证明与胱抑素B^[8]^[9]和组织蛋白酶L1^[9]^[10]产生相互作用。

参见

肽转运蛋白碳饥饿家族

参考文献

^ 與血清胱抑素A相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000121552 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000094733 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hsieh WT, Barrick JL, Berrettini WH, Chan MM, Fong D. A PstI DNA polymorphism in the human stefin A gene (STF 1). Nucleic Acids Res. Jun 1991, 19 (7): 1722. PMC 333958 . PMID 1674139. doi:10.1093/nar/19.7.1722-a.
^ ^7.0 ^7.1 Entrez Gene: CSTA cystatin A (stefin A).
^ Pavlova, Alona; Björk Ingemar. Grafting of features of cystatins C or B into the N-terminal region or second binding loop of cystatin A (stefin A) substantially enhances inhibition of cysteine proteinases. Biochemistry (United States). Sep 2003, 42 (38): 11326–33. ISSN 0006-2960. PMID 14503883. doi:10.1021/bi030119v.
^ ^9.0 ^9.1 Estrada, S; Nycander M; Hill N J; Craven C J; Waltho J P; Björk I. The role of Gly-4 of human cystatin A (stefin A) in the binding of target proteinases. Characterization by kinetic and equilibrium methods of the interactions of cystatin A Gly-4 mutants with papain, cathepsin B, and cathepsin L. Biochemistry (UNITED STATES). May 1998, 37 (20): 7551–60. ISSN 0006-2960. PMID 9585570. doi:10.1021/bi980026r.
^ Majerle, Andreja; Jerala Roman. Protein inhibitors form complexes with procathepsin L and augment cleavage of the propeptide. Arch. Biochem. Biophys. (United States). Sep 2003, 417 (1): 53–8. ISSN 0003-9861. PMID 12921779. doi:10.1016/S0003-9861(03)00319-9.

阅读

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