3-哌啶甲酸
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| 識別資訊 | |
|---|---|
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| CAS號 | 498-95-3 |
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.007.159 |
| 化學資訊 | |
| 化學式 | C6H11NO2 |
| 摩爾質量 | 129.16 g·mol−1 |
| 3D模型（JSmol） | |
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3-哌啶甲酸是一種有機化合物，化學式為C6H11NO2，它是可溶於水的白色晶體。[1]
合成與性質
3-哌啶甲酸可由煙酸的氫化反應製得。
它和乙醇在酸的催化下進行酯化反應，得到3-哌啶甲酸乙酯。[2]
3-哌啶甲酸是一種Γ-氨基丁酸（GABA）再攝取抑制劑[3]，常用於相關研究[4][5]。
參考文獻
- ^ 3-哌啶甲酸 （頁面存檔備份，存於互聯網檔案館）. ChemicalBook. [2019-3-22]
- ^ 李運波，唐鳳翔，孟春 等. 3-哌啶甲酸及其衍生物的合成與應用研究進展（PDF （頁面存檔備份，存於互聯網檔案館））. 有機化學, 2009, 29(7).
- ^ Macdonald, R.L. Eadie, Mervyn J.; Vajda, Frank J. E. , 編. Antiepileptic drugs: pharmacology and therapeutics First. [S.l.]: Springer. 2012: 130. ISBN 978-3-642-64244-9.
In contrast, prolonged (1 h) exposure to gabapentin enhanced the shunting effect on CAl region excitatory postsynaptic potentials induced by the GABA uptake inhibitor, nipecotic acid, which promotes GABA release.
- ^ Takahashi K, Miyoshi S, Kaneko A, Copenhagen DR. Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina. Jpn. J. Physiol. 1995, 45 (3): 457–73 [2019-03-22]. PMID 7474528. doi:10.2170/jjphysiol.45.457. （原始內容存檔於2020-02-02）.
- ^ Wahab A, Heinemann U, Albus K. Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Research. October 2009, 86 (2-3): 113–23 [2019-03-22]. PMID 19535226. doi:10.1016/j.eplepsyres.2009.05.008. （原始內容存檔於2020-02-02）.