3-哌啶甲酸
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| 识别信息 | |
|---|---|
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| CAS号 | 498-95-3 |
| PubChem CID | |
| IUPHAR/BPS | |
| ChemSpider | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.007.159 |
| 化学信息 | |
| 化学式 | C6H11NO2 |
| 摩尔质量 | 129.16 g·mol−1 |
| 3D模型（JSmol） | |
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3-哌啶甲酸是一种有机化合物，化学式为C6H11NO2，它是可溶于水的白色晶体。[1]
合成与性质
3-哌啶甲酸可由烟酸的氢化反应制得。
它和乙醇在酸的催化下进行酯化反应，得到3-哌啶甲酸乙酯。[2]
3-哌啶甲酸是一种Γ-氨基丁酸（GABA）再攝取抑制劑[3]，常用于相关研究[4][5]。
参考文献
- ^ 3-哌啶甲酸 （页面存档备份，存于互联网档案馆）. ChemicalBook. [2019-3-22]
- ^ 李运波，唐凤翔，孟春 等. 3-哌啶甲酸及其衍生物的合成与应用研究进展（PDF （页面存档备份，存于互联网档案馆））. 有机化学, 2009, 29(7).
- ^ Macdonald, R.L. Eadie, Mervyn J.; Vajda, Frank J. E. , 编. Antiepileptic drugs: pharmacology and therapeutics First. [S.l.]: Springer. 2012: 130. ISBN 978-3-642-64244-9.
In contrast, prolonged (1 h) exposure to gabapentin enhanced the shunting effect on CAl region excitatory postsynaptic potentials induced by the GABA uptake inhibitor, nipecotic acid, which promotes GABA release.
- ^ Takahashi K, Miyoshi S, Kaneko A, Copenhagen DR. Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina. Jpn. J. Physiol. 1995, 45 (3): 457–73 [2019-03-22]. PMID 7474528. doi:10.2170/jjphysiol.45.457. （原始内容存档于2020-02-02）.
- ^ Wahab A, Heinemann U, Albus K. Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Research. October 2009, 86 (2-3): 113–23 [2019-03-22]. PMID 19535226. doi:10.1016/j.eplepsyres.2009.05.008. （原始内容存档于2020-02-02）.