胱天蛋白酶14

胱天蛋白酶14
識別號
別名	CASP14；, caspase 14, ARCI12
外部ID	OMIM：605848 MGI：1335092 HomoloGene：36304 GeneCards：CASP14
為以下藥物的標靶
	emricasan
基因位置（人類）
染色體	19號染色體
終止	15,058,293 bp
基因位置（小鼠）
染色體	小鼠10號染色體
終止	78,554,128 bp
基因本體
分子功能	• 肽酶活性; • cysteine-type endopeptidase activity; • 半胱氨酸型肽酶活性; • 血漿蛋白結合; • 水解酶活性; • endopeptidase activity; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity involved in apoptotic process;
細胞組分	• 細胞質; • keratin filament; • 細胞核; • 細胞質基質; • 線粒體;
生物學過程	• 細胞角質化; • 細胞分化; • keratinization; • 蛋白酶解; • epidermis development; • execution phase of apoptosis; • 細胞凋亡; • intrinsic apoptotic signaling pathway in response to DNA damage;
	Sources:Amigo / QuickGO
直系同源
	23581
	12365
	ENSG00000105141
	ENSMUSG00000005355
	P31944
	O89094
	NM_012114
	NM_009809
	NP_036246
	NP_033939
	維基數據
檢視/編輯人類	檢視/編輯小鼠

胱天蛋白酶14（英語：Caspase 14）是一種在人類中由CASP14基因編碼的酶。^[6]^[7]^[8]

胱天蛋白酶14屬於胱天蛋白酶家族的成員。胱天蛋白酶的連續活化在細胞凋亡的執行階段發揮着核心作用。胱天蛋白酶以無活性的酶原形式存在，在保守的天冬氨酸殘基處經歷蛋白水解加工，產生一大一小兩個亞基，然後二聚化形成活性酶。該酶已被證明在體外被胱天蛋白酶8和10加工和活化，而在體內則被抗Fas促效劑抗體或TNF相關凋亡誘導配體加工和活化。這種胱天蛋白酶的表達和加工可能參與角質形成細胞終末分化，這對於皮膚屏障的形成很重要。^[8]

根據人類蛋白質圖譜（英語：Human Protein Atlas）^[9]，CASP14蛋白在人類皮膚中富集，主要表達於表皮上層。根據細胞圖譜，該蛋白質主要定位於細胞質。^[10]

參見

蛋白酶解圖譜（英語：The Proteolysis Map）
胱天蛋白酶

參考文獻

^ 對Caspase 14起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000105141 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000005355 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P. Identification of a new caspase homologue: caspase-14. Cell Death Differ. May 1999, 5 (10): 838–46. PMID 10203698. doi:10.1038/sj.cdd.4400444 .
^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. Caspase-14 is a novel developmentally regulated protease. J Biol Chem. Dec 1998, 273 (45): 29648–53. PMID 9792675. doi:10.1074/jbc.273.45.29648 .
^ ^8.0 ^8.1 Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase.
^ Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina. Tissue-based map of the human proteome. Science. 2015-01-23, 347 (6220): 1260419. ISSN 0036-8075. PMID 25613900. S2CID 802377. doi:10.1126/science.1260419 （英語）.
^ Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars. A subcellular map of the human proteome. Science. 2017-05-26, 356 (6340): eaal3321. ISSN 0036-8075. PMID 28495876. S2CID 10744558. doi:10.1126/science.aal3321 （英語）.

拓展閱讀

Rasmussen HH, van Damme J, Puype M, et al. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.. Electrophoresis. 1993, 13 (12): 960–9. PMID 1286667. S2CID 41855774. doi:10.1002/elps.11501301199.
Ahmad M, Srinivasula SM, Hegde R, et al. Identification and characterization of murine caspase-14, a new member of the caspase family.. Cancer Res. 1998, 58 (22): 5201–5. PMID 9823333.
Eckhart L, Ban J, Fischer H, Tschachler E. Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation.. Biochem. Biophys. Res. Commun. 2000, 277 (3): 655–9. PMID 11062009. doi:10.1006/bbrc.2000.3698.
Eckhart L, Declercq W, Ban J, et al. Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.. J. Invest. Dermatol. 2001, 115 (6): 1148–51. PMID 11121154. doi:10.1046/j.1523-1747.2000.00205.x .
Lippens S, Kockx M, Knaapen M, et al. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.. Cell Death Differ. 2001, 7 (12): 1218–24. PMID 11175259. doi:10.1038/sj.cdd.4400785 .
Pistritto G, Jost M, Srinivasula SM, et al. Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.. Cell Death Differ. 2003, 9 (9): 995–1006. PMID 12181750. S2CID 23933663. doi:10.1038/sj.cdd.4401061.
Chien AJ, Presland RB, Kuechle MK. Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.. Biochem. Biophys. Res. Commun. 2002, 296 (4): 911–7. PMID 12200134. doi:10.1016/S0006-291X(02)02015-6.
Rendl M, Ban J, Mrass P, et al. Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner.. J. Invest. Dermatol. 2003, 119 (5): 1150–5. PMID 12445205. doi:10.1046/j.1523-1747.2002.19532.x .
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Lippens S, Kockx M, Denecker G, et al. Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.. Am. J. Pathol. 2004, 165 (3): 833–41. PMC 1618612 . PMID 15331408. doi:10.1016/s0002-9440(10)63346-9.
Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Walsh DS, Borke JL, Singh BB, et al. Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation.. J. Dermatol. Sci. 2005, 37 (1): 61–3 [2024-02-25]. PMID 15619438. doi:10.1016/j.jdermsci.2004.10.003. （原始內容存檔於2023-03-30）.
Koenig U, Sommergruber W, Lippens S. Aberrant expression of caspase-14 in epithelial tumors.. Biochem. Biophys. Res. Commun. 2005, 335 (2): 309–13. PMID 16061209. doi:10.1016/j.bbrc.2005.07.072.
Krajewska M, Kim H, Shin E, et al. Tumor-associated alterations in caspase-14 expression in epithelial malignancies.. Clin. Cancer Res. 2006, 11 (15): 5462–71. PMID 16061862. doi:10.1158/1078-0432.CCR-04-2527 .
Kam DW, Charles AK, Dharmarajan AM. Caspase-14 expression in the human placenta.. Reprod. Biomed. Online. 2005, 11 (2): 236–43. PMID 16168224. doi:10.1016/S1472-6483(10)60964-9 .
Park K, Kuechle MK, Choe Y, et al. Expression and characterization of constitutively active human caspase-14.. Biochem. Biophys. Res. Commun. 2006, 347 (4): 941–8. PMID 16854378. doi:10.1016/j.bbrc.2006.06.156.
White L, Dharmarajan A, Charles A. Caspase-14: a new player in cytotrophoblast differentiation.. Reprod. Biomed. Online. 2007, 14 (3): 300–7. PMID 17359582. doi:10.1016/S1472-6483(10)60871-1 .
Hsu S, Qin H, Dickinson D, et al. Expression of caspase-14 reduces tumorigenicity of skin cancer cells.. In Vivo. 2007, 21 (2): 279–83. PMID 17436577.

外部連結

肽酶及其抑制劑的MEROPS在線數據庫：C14.018 （頁面存檔備份，存於互聯網檔案館）

[1] 對Caspase 14起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000105141 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000005355 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10203698-6] Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P. Identification of a new caspase homologue: caspase-14. Cell Death Differ. May 1999, 5 (10): 838–46. PMID 10203698. doi:10.1038/sj.cdd.4400444 .

[pmid9792675-7] Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. Caspase-14 is a novel developmentally regulated protease. J Biol Chem. Dec 1998, 273 (45): 29648–53. PMID 9792675. doi:10.1074/jbc.273.45.29648 .

[entrez-8] 8.0 ^8.1 Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase.

[9] Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina. Tissue-based map of the human proteome. Science. 2015-01-23, 347 (6220): 1260419. ISSN 0036-8075. PMID 25613900. S2CID 802377. doi:10.1126/science.1260419 （英語）.

[10] Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars. A subcellular map of the human proteome. Science. 2017-05-26, 356 (6340): eaal3321. ISSN 0036-8075. PMID 28495876. S2CID 10744558. doi:10.1126/science.aal3321 （英語）.

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閱論編蛋白酶類：半胱氨酸蛋白酶類（EC 3.4.22)
胱天蛋白酶	胱天蛋白酶1 胱天蛋白酶2 胱天蛋白酶3 胱天蛋白酶4 胱天蛋白酶5 胱天蛋白酶6 胱天蛋白酶7 胱天蛋白酶8 胱天蛋白酶9 胱天蛋白酶10 胱天蛋白酶11 胱天蛋白酶12 胱天蛋白酶13 胱天蛋白酶14
來自果實	木瓜蛋白酶無花果蛋白酶（英語：Ficain）鳳梨蛋白酶獼猴桃蛋白酶
鈣蛋白酶	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
組織蛋白酶	B C F H K L1/L2 O S T W Z
其它	梭菌蛋白酶癌性促凝物質分離酶（英語：Separase） Autophagin Cruzipain 3C樣蛋白酶
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3（英語：Template:Ligases CO CS and CN）/4/5-6

閱論編酶
活性	活性位點結合位點催化三聯體負氧離子洞酶催化混雜（英語：Enzyme promiscuity）催化最適酶（英語：Catalytically perfect enzyme）輔因子輔酶酶促反應
調節	變構調節協同性（英語：Cooperativity）酶抑制劑酶活化劑
分類	EC編號蛋白質超家族蛋白質家族酶列表
動力學	酶動力學伊迪-霍夫斯蒂圖（英語：Eadie–Hofstee diagram）哈尼斯-伍爾夫圖（英語：Hanes–Woolf plot）雙倒數圖米氏動力學
類型	EC1 氧化還原酶（列表（英語：List of EC numbers (EC 1)）） EC2 轉移酶（列表（英語：List of EC numbers (EC 2)）） EC3 水解酶（列表（英語：List of EC numbers (EC 3)）） EC4 裂解酶（列表（英語：List of EC numbers (EC 4)）） EC5 異構酶（列表（英語：List of EC numbers (EC 5)）） EC6 連接酶（列表（英語：List of EC numbers (EC 6)）） EC7 移位酶（英語：Translocase）（列表（英語：List of EC numbers (EC 7)））