胱天蛋白酶14

胱天蛋白酶14
识别号
别名	CASP14；, caspase 14, ARCI12
外部ID	OMIM：605848 MGI：1335092 HomoloGene：36304 GeneCards：CASP14
为以下药物的标靶
	emricasan
基因位置（人类）
染色体	19号染色体
终止	15,058,293 bp
基因位置（小鼠）
染色体	小鼠10号染色体
终止	78,554,128 bp
基因本体
分子功能	• 肽酶活性; • cysteine-type endopeptidase activity; • 半胱氨酸型肽酶活性; • 血浆蛋白结合; • 水解酶活性; • endopeptidase activity; • cysteine-type endopeptidase activity involved in execution phase of apoptosis; • cysteine-type endopeptidase activity involved in apoptotic process;
细胞组分	• 细胞质; • keratin filament; • 细胞核; • 细胞质基质; • 线粒体;
生物学过程	• cornification; • 细胞分化; • keratinization; • 蛋白酶解; • epidermis development; • execution phase of apoptosis; • 细胞凋亡; • intrinsic apoptotic signaling pathway in response to DNA damage;
	Sources:Amigo / QuickGO
直系同源
	23581
	12365
	ENSG00000105141
	ENSMUSG00000005355
	P31944
	O89094
	NM_012114
	NM_009809
	NP_036246
	NP_033939
	维基数据
查看/编辑人类	查看/编辑小鼠

胱天蛋白酶14（英语：Caspase 14）是一种在人类中由CASP14基因编码的酶。^[6]^[7]^[8]

胱天蛋白酶14属于胱天蛋白酶家族的成员。胱天蛋白酶的连续激活在细胞凋亡的执行阶段发挥着核心作用。胱天蛋白酶以无活性的酶原形式存在，在保守的天冬氨酸残基处经历蛋白水解加工，产生一大一小两个亚基，然后二聚化形成活性酶。该酶已被证明在体外被胱天蛋白酶8和10加工和激活，而在体内则被抗Fas激动剂抗体或TNF相关凋亡诱导配体加工和激活。这种胱天蛋白酶的表达和加工可能参与角质形成细胞终末分化，这对于皮肤屏障的形成很重要。^[8]

根据人类蛋白质图谱（英语：Human Protein Atlas）^[9]，CASP14蛋白在人类皮肤中富集，主要表达于表皮上层。根据细胞图谱，该蛋白质主要定位于细胞质。^[10]

参见

蛋白酶解图谱（英语：The Proteolysis Map）
胱天蛋白酶

参考文献

^ 對Caspase 14起作用的藥物；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000105141 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000005355 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P. Identification of a new caspase homologue: caspase-14. Cell Death Differ. May 1999, 5 (10): 838–46. PMID 10203698. doi:10.1038/sj.cdd.4400444 .
^ Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. Caspase-14 is a novel developmentally regulated protease. J Biol Chem. Dec 1998, 273 (45): 29648–53. PMID 9792675. doi:10.1074/jbc.273.45.29648 .
^ ^8.0 ^8.1 Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase.
^ Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina. Tissue-based map of the human proteome. Science. 2015-01-23, 347 (6220): 1260419. ISSN 0036-8075. PMID 25613900. S2CID 802377. doi:10.1126/science.1260419 （英语）.
^ Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars. A subcellular map of the human proteome. Science. 2017-05-26, 356 (6340): eaal3321. ISSN 0036-8075. PMID 28495876. S2CID 10744558. doi:10.1126/science.aal3321 （英语）.

拓展阅读

Rasmussen HH, van Damme J, Puype M, et al. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.. Electrophoresis. 1993, 13 (12): 960–9. PMID 1286667. S2CID 41855774. doi:10.1002/elps.11501301199.
Ahmad M, Srinivasula SM, Hegde R, et al. Identification and characterization of murine caspase-14, a new member of the caspase family.. Cancer Res. 1998, 58 (22): 5201–5. PMID 9823333.
Eckhart L, Ban J, Fischer H, Tschachler E. Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation.. Biochem. Biophys. Res. Commun. 2000, 277 (3): 655–9. PMID 11062009. doi:10.1006/bbrc.2000.3698.
Eckhart L, Declercq W, Ban J, et al. Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.. J. Invest. Dermatol. 2001, 115 (6): 1148–51. PMID 11121154. doi:10.1046/j.1523-1747.2000.00205.x .
Lippens S, Kockx M, Knaapen M, et al. Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.. Cell Death Differ. 2001, 7 (12): 1218–24. PMID 11175259. doi:10.1038/sj.cdd.4400785 .
Pistritto G, Jost M, Srinivasula SM, et al. Expression and transcriptional regulation of caspase-14 in simple and complex epithelia.. Cell Death Differ. 2003, 9 (9): 995–1006. PMID 12181750. S2CID 23933663. doi:10.1038/sj.cdd.4401061.
Chien AJ, Presland RB, Kuechle MK. Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation.. Biochem. Biophys. Res. Commun. 2002, 296 (4): 911–7. PMID 12200134. doi:10.1016/S0006-291X(02)02015-6.
Rendl M, Ban J, Mrass P, et al. Caspase-14 expression by epidermal keratinocytes is regulated by retinoids in a differentiation-associated manner.. J. Invest. Dermatol. 2003, 119 (5): 1150–5. PMID 12445205. doi:10.1046/j.1523-1747.2002.19532.x .
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Lippens S, Kockx M, Denecker G, et al. Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures.. Am. J. Pathol. 2004, 165 (3): 833–41. PMC 1618612 . PMID 15331408. doi:10.1016/s0002-9440(10)63346-9.
Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Walsh DS, Borke JL, Singh BB, et al. Psoriasis is characterized by altered epidermal expression of caspase 14, a novel regulator of keratinocyte terminal differentiation and barrier formation.. J. Dermatol. Sci. 2005, 37 (1): 61–3 [2024-02-25]. PMID 15619438. doi:10.1016/j.jdermsci.2004.10.003. （原始内容存档于2023-03-30）.
Koenig U, Sommergruber W, Lippens S. Aberrant expression of caspase-14 in epithelial tumors.. Biochem. Biophys. Res. Commun. 2005, 335 (2): 309–13. PMID 16061209. doi:10.1016/j.bbrc.2005.07.072.
Krajewska M, Kim H, Shin E, et al. Tumor-associated alterations in caspase-14 expression in epithelial malignancies.. Clin. Cancer Res. 2006, 11 (15): 5462–71. PMID 16061862. doi:10.1158/1078-0432.CCR-04-2527 .
Kam DW, Charles AK, Dharmarajan AM. Caspase-14 expression in the human placenta.. Reprod. Biomed. Online. 2005, 11 (2): 236–43. PMID 16168224. doi:10.1016/S1472-6483(10)60964-9 .
Park K, Kuechle MK, Choe Y, et al. Expression and characterization of constitutively active human caspase-14.. Biochem. Biophys. Res. Commun. 2006, 347 (4): 941–8. PMID 16854378. doi:10.1016/j.bbrc.2006.06.156.
White L, Dharmarajan A, Charles A. Caspase-14: a new player in cytotrophoblast differentiation.. Reprod. Biomed. Online. 2007, 14 (3): 300–7. PMID 17359582. doi:10.1016/S1472-6483(10)60871-1 .
Hsu S, Qin H, Dickinson D, et al. Expression of caspase-14 reduces tumorigenicity of skin cancer cells.. In Vivo. 2007, 21 (2): 279–83. PMID 17436577.

外部链接

肽酶及其抑制剂的MEROPS在线数据库：C14.018 （页面存档备份，存于互联网档案馆）

[1] 對Caspase 14起作用的藥物；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000105141 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000005355 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10203698-6] Van de Craen M, Van Loo G, Pype S, Van Criekinge W, Van den brande I, Molemans F, Fiers W, Declercq W, Vandenabeele P. Identification of a new caspase homologue: caspase-14. Cell Death Differ. May 1999, 5 (10): 838–46. PMID 10203698. doi:10.1038/sj.cdd.4400444 .

[pmid9792675-7] Hu S, Snipas SJ, Vincenz C, Salvesen G, Dixit VM. Caspase-14 is a novel developmentally regulated protease. J Biol Chem. Dec 1998, 273 (45): 29648–53. PMID 9792675. doi:10.1074/jbc.273.45.29648 .

[entrez-8] 8.0 ^8.1 Entrez Gene: CASP14 caspase 14, apoptosis-related cysteine peptidase.

[9] Uhlén, Mathias; Fagerberg, Linn; Hallström, Björn M.; Lindskog, Cecilia; Oksvold, Per; Mardinoglu, Adil; Sivertsson, Åsa; Kampf, Caroline; Sjöstedt, Evelina. Tissue-based map of the human proteome. Science. 2015-01-23, 347 (6220): 1260419. ISSN 0036-8075. PMID 25613900. S2CID 802377. doi:10.1126/science.1260419 （英语）.

[10] Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Blal, Hammou Ait; Alm, Tove; Asplund, Anna; Björk, Lars. A subcellular map of the human proteome. Science. 2017-05-26, 356 (6340): eaal3321. ISSN 0036-8075. PMID 28495876. S2CID 10744558. doi:10.1126/science.aal3321 （英语）.

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查论编蛋白酶类：半胱氨酸蛋白酶类（EC 3.4.22)
胱天蛋白酶	胱天蛋白酶1 胱天蛋白酶2 胱天蛋白酶3 胱天蛋白酶4 胱天蛋白酶5 胱天蛋白酶6 胱天蛋白酶7 胱天蛋白酶8 胱天蛋白酶9 胱天蛋白酶10 胱天蛋白酶11 胱天蛋白酶12 胱天蛋白酶13 胱天蛋白酶14
来自果实	木瓜蛋白酶无花果蛋白酶（英语：Ficain）凤梨蛋白酶猕猴桃蛋白酶
钙蛋白酶	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
组织蛋白酶	B C F H K L1/L2 O S T W Z
其它	梭菌蛋白酶癌性促凝物质分离酶（英语：Separase） Autophagin Cruzipain 3C样蛋白酶
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3（英语：Template:Ligases CO CS and CN）/4/5-6

查论编酶
活性	活性位点结合位点催化三联体负氧离子洞酶催化混杂（英语：Enzyme promiscuity）催化最适酶（英语：Catalytically perfect enzyme）辅因子辅酶酶促反应
调节	别构调节协同性（英语：Cooperativity）酶抑制剂酶激活剂
分类	EC编号蛋白质超家族蛋白质家族酶列表
动力学	酶动力学伊迪-霍夫斯蒂图（英语：Eadie–Hofstee diagram）哈尼斯-伍尔夫图（英语：Hanes–Woolf plot）双倒数图米氏动力学
类型	EC1 氧化还原酶（列表（英语：List of EC numbers (EC 1)）） EC2 转移酶（列表（英语：List of EC numbers (EC 2)）） EC3 水解酶（列表（英语：List of EC numbers (EC 3)）） EC4 裂合酶（列表（英语：List of EC numbers (EC 4)）） EC5 异构酶（列表（英语：List of EC numbers (EC 5)）） EC6 连接酶（列表（英语：List of EC numbers (EC 6)）） EC7 移位酶（英语：Translocase）（列表（英语：List of EC numbers (EC 7)））