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STAT1

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維基百科，自由的百科全書
STAT1
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
別名STAT1；, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
外部IDOMIM：600555 MGI：103063 HomoloGene：21428 GeneCards：STAT1
相關疾病
慢性黏膜皮膚念珠菌病、​susceptibility to viral and mycobacterial infections[1]
基因位置（人類）
2號染色體
染色體2號染色體[2]
2號染色體
STAT1的基因位置
STAT1的基因位置
基因座2q32.2起始190,908,460 bp[2]
終止191,020,960 bp[2]
RNA表達模式
查閱更多表達數據
直系同源
物種人類小鼠
Entrez

6772

20846

Ensembl

ENSG00000115415

ENSMUSG00000026104

UniProt

P42224

P42225

mRNA​序列

​NM_007315
​NM_139266

NM_001205313
​NM_001205314
​NM_009283
​NM_001357627

蛋白序列

NP_009330
​NP_644671

無數據

基因位置​（UCSC）Chr 2: 190.91 – 191.02 MbChr 1: 52.16 – 52.2 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

STAT1是轉錄因子中信號轉導及轉錄激活蛋白（STAT蛋白）家族的一員。

STAT1涉及I型、II型或III型干擾素激活基因的正調控。在干擾素-γ刺激下，STAT1會組成同源二聚體或與STAT3組成異二聚體結合到GAS（Interferon-Gamma-Activated Sequence，干擾素γ激活序列）啟動子上；而在干擾素-α或干擾素-β刺激下，STAT1會與STAT2組成異二聚體結合到ISRE（Interferon-Stimulated Response Element，干擾素激活反應元件）啟動子上[6]。在這兩種情況下，STAT二聚體與啟動子的結合都會導致ISG（Interferon-Stimulated Genes，干擾素激活基因）的表達。

STAT1可由二烯丙基二硫誘導表達[7]

相互作用

STAT1能與下列蛋白質發生相互作用：

參考文獻

  1. ^ 與STAT1相關的疾病；在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000115415 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026104 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Michael G. Katze; Yupeng He & Michael Gale; et al. Viruses and interferon: a fight for supremacy. Nature Reviews Immunology. 2002, 2 (9): 675–87. PMID 12209136. doi:10.1038/nri888. 
  7. ^ Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR. Cancer Genomics Proteomics. 2007, 4 (2): 93–7. PMID 17804871. 
  8. ^ Wong, A H; Tam N W, Yang Y L, Cuddihy A R, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas A E. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways. EMBO J. (ENGLAND). March 1997, 16 (6): 1291–304. ISSN 0261-4189. PMC 1169727 可免費查閱. PMID 9135145. doi:10.1093/emboj/16.6.1291. 
  9. ^ Wong, A H; Durbin J E, Li S, Dever T E, Decker T, Koromilas A E. Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR. J. Biol. Chem. (United States). April 2001, 276 (17): 13727–37. ISSN 0021-9258. PMID 11278865. doi:10.1074/jbc.M011240200. 
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  16. ^ Zhang, J J; Zhao Y, Chait B T, Lathem W W, Ritzi M, Knippers R, Darnell J E. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J. (ENGLAND). Dec 1998, 17 (23): 6963–71. ISSN 0261-4189. PMC 1171044 可免費查閱. PMID 9843502. doi:10.1093/emboj/17.23.6963. 
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  18. ^ Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. (United States). March 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790. 
  19. ^ Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J. Biol. Chem. (United States). August 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059. 
  20. ^ Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J. Biol. Chem. (United States). August 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200. 
  21. ^ Deberry, C; Mou S, Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem. J. (ENGLAND). October 1997, 327 (1): 73–80. ISSN 0264-6021. PMC 1218765 可免費查閱. PMID 9355737. 
  22. ^ Pang, Q; Fagerlie S, Christianson T A, Keeble W, Faulkner G, Diaz J, Rathbun R K, Bagby G C. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol. Cell. Biol. (United States). July 2000, 20 (13): 4724–35. ISSN 0270-7306. PMC 85895 可免費查閱. PMID 10848598. doi:10.1128/MCB.20.13.4724-4735.2000. 
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  30. ^ 30.0 30.1 Kristof, Arnold S; Marks-Konczalik Joanna, Billings Eric, Moss Joel. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin. J. Biol. Chem. (United States). September 2003, 278 (36): 33637–44. ISSN 0021-9258. PMID 12807916. doi:10.1074/jbc.M301053200. 
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  35. ^ Vidal, Marcos; Ramana Chilakamarti V, Dusso Adriana S. Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription. Mol. Cell. Biol. (United States). April 2002, 22 (8): 2777–87. ISSN 0270-7306. PMC 133712 可免費查閱. PMID 11909970. doi:10.1128/MCB.22.8.2777-2787.2002. 
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延伸閱讀

外部連結

取自「https://zh.wikipedia.org/w/index.php?title=STAT1&oldid=82737355」