5-氟二甲基色胺

5-氟二甲基色胺
識別資訊
	IUPAC命名法 2-(5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine; ;
CAS號	22120-36-1
PubChem CID	2762738;
ChemSpider	2043436 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID30376407 ;
化學資訊
化學式	C12H15FN2
摩爾質量	206.26 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES CN(C)CCC1=CNC2=C1C=C(C=C2)F;
	InChI InChI=1S/C12H15FN2/c1-15(2)6-5-9-8-14-12-4-3-10(13)7-11(9)12/h3-4,7-8,14H,5-6H2,1-2H3 ; Key:BXYDWQABVPBLBU-UHFFFAOYSA-N ;

5-氟-N,N-二甲基色胺（英語：5-Fluoro-N,N-dimethyltryptamine，簡稱5-fluoro-DMT，5-氟二甲基色胺）是一種色胺衍生物，類似於5-溴二甲基色胺和5-甲氧基二甲基色胺。二甲基色胺的氟取代對其與5-HT_2A/C受體的親和性影響不大，但6-氟二乙基色胺對5-HT_2A受體的激動性幾乎無效，而4-氟-5-甲基二甲基色胺卻是5-HT_1A受體的強激動劑^[1]^[2]。

參考文獻

^ Blair, JB; Kurrasch-Orbaugh, D; Marona-Lewicka, D; Cumbay, MG; Watts, VJ; Barker, EL; Nichols, DE. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 2000, 43 (24): 4701–10. PMID 11101361. doi:10.1021/jm000339w.
^ Rabin, RA; Regina, M; Doat, M; Winter, JC. 5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens. Pharmacology, Biochemistry, and Behavior. 2002, 72 (1–2): 29–37. PMID 11900766. doi:10.1016/S0091-3057(01)00720-1.

外部連結

6-Fluoro-DET（頁面存檔備份，存於網際網路檔案館）

[1] Blair, JB; Kurrasch-Orbaugh, D; Marona-Lewicka, D; Cumbay, MG; Watts, VJ; Barker, EL; Nichols, DE. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 2000, 43 (24): 4701–10. PMID 11101361. doi:10.1021/jm000339w.

[2] Rabin, RA; Regina, M; Doat, M; Winter, JC. 5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens. Pharmacology, Biochemistry, and Behavior. 2002, 72 (1–2): 29–37. PMID 11900766. doi:10.1016/S0091-3057(01)00720-1.

[1]

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