Talk:谷氨酸脱羧酶
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未翻譯內容
未翻譯內容如下:--Flame 歡迎泡茶 2011年6月19日 (日) 00:28 (UTC)
糖尿病
Both GAD67 and GAD65 are targets of autoantibodies in people who later develop type 1 diabetes mellitus or latent autoimmune diabetes.[1][2] Injections with GAD65 has been shown to preserve some insulin production for 30 months in humans with type 1 diabetes.[3][4]
精神分裂症与双相型障碍
GAD mRNA表达的大量失调,coupled with downregulation of reelin, is observed in 精神分裂症 and 双相障碍.[5] The most pronounced downregulation of GAD67 was found in hippocampal stratum oriens layer in both disorders and in other layers and structures of hippocampus with varying degrees.[6]
药物引起的改变
普瑞巴林,一种抗癫痫药, increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity.[1] Extracts from Centella asiatica (gotu kola) and Valeriana officinalis (valerian) stimulated GAD activity.[7]
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祝编安。—InternetArchiveBot (報告軟件缺陷) 2017年7月22日 (六) 05:43 (UTC)
- ^ Baekkeskov S, Aanstoot HJ, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Olesen H, De Camilli P, Camilli PD. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature. 1990, 347 (6289): 151–6. PMID 1697648. doi:10.1038/347151a0.
- ^ Kaufman DL, Erlander MG, Clare-Salzler M, Atkinson MA, Maclaren NK, Tobin AJ. Autoimmunity to two forms of 谷氨酸脱羧酶 in insulin-dependent diabetes mellitus. J. Clin. Invest. 1992, 89 (1): 283–92. PMC 442846 . PMID 1370298. doi:10.1172/JCI115573.
- ^ Ludvigsson J, Faresjö M, Hjorth M, Axelsson S, Chéramy M, Pihl M, Vaarala O, Forsander G, Ivarsson S, Johansson C, Lindh A, Nilsson NO, Aman J, Ortqvist E, Zerhouni P, Casas R. GAD treatment and insulin secretion in recent-onset type 1 diabetes. N. Engl. J. Med. 2008, 359 (18): 1909–20. PMID 18843118. doi:10.1056/NEJMoa0804328. 已忽略未知参数
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) (帮助) - ^ Diamyd announces completion of type 1 diabetes vaccine trial with long term efficacy demonstrated at 30 months. Press Release. Diamyd Medical AB. 2008-01-28 [2010-01-13].
- ^ Woo TU, Walsh JP, Benes FM. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Arch. Gen. Psychiatry. 2004, 61 (7): 649–57. PMID 15237077. doi:10.1001/archpsyc.61.7.649.
- ^ Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M. Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (24): 10164–9. PMC 1888575 . PMID 17553960. doi:10.1073/pnas.0703806104.
- ^ pmid18066140, F; Schjøtt J. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Canadian Journal of Physiology and Pharmacology. 2007, 85 (9): 933–42. PMID 18066140. doi:10.4045/tidsskr.08.0047. 已忽略未知参数
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