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组氨酸脱羧酶

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组氨酸脱羧酶
在组氨酸脱羧酶作用下从組氨酸組織胺的转化
识别码
EC編號 4.1.1.22
CAS号 9024-61-7
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum
基因本体 AmiGO / EGO
组氨酸脱羧酶
标识
代号 HDC; MGC163399
扩展标识 遗传学142704 鼠基因96062 同源基因20490 GeneCards: HDC Gene
EC編號 4.1.1.22
直系同源体
物种 人类 小鼠
Entrez 3067 15186
Ensembl ENSG00000140287 ENSMUSG00000027360
UniProt P19113 P23738
mRNA序列 NM_002112 NM_008230
蛋白序列 NP_002103 NP_032256
基因位置 Chr 15:
48.32 – 48.35 Mb
Chr 2:
126.42 – 126.44 Mb
PubMed查询 [1] [2]

组氨酸脱羧酶(英語:Histidine decarboxylaseHDC)是一种以如下方式在维生素B6的帮助下催化从組氨酸生成組織胺的反应的[1][2][3]

C6H9N3O2C5H9N3 + CO2

组氨酸脱羧酶能转变組氨酸組織胺

在人体中,组氨酸脱羧酶由HDC基因编码。[4][5]

生物胺组织胺在许多生理过程中有重要的调节作用,包括神经传递、胃酸分泌、平滑肌舒张。从组氨酸组织胺的生物合成由L-组氨酸脱羧酶催化。这个同源二聚体酶是一个依赖磷酸吡哆醛(PLP)的脱羧酶,并对其底物组氨酸有高度特异性。[4]

参考

  1. ^ Epps HM. Studies on bacterial amino-acid decarboxylases: 4. l(-)-histidine decarboxylase from Cl. welchii Type A. Biochem. J. 1945, 39 (1): 42–6. PMC 1258146可免费查阅. PMID 16747851. 
  2. ^ Riley WD, Snell EE. Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group. Biochemistry. October 1968, 7 (10): 3520–8. PMID 5681461. 
  3. ^ Rosenthaler J, Guirard BM, Chang GW, Snell EE. Purification and properties of histidine decarboxylase from Lactobacillus 30a. Proc. Natl. Acad. Sci. U.S.A. July 1965, 54 (1): 152–8. PMC 285813可免费查阅. PMID 5216347. 
  4. ^ 4.0 4.1 Entrez Gene: histidine decarboxylase. (原始内容存档于2020-03-28). 
  5. ^ Bruneau G, Nguyen VC, Gros F, Bernheim A, Thibault J. Preparation of a rat brain histidine decarboxylase (HDC) cDNA probe by PCR and assignment of the human HDC gene to chromosome 15. Hum. Genet. November 1992, 90 (3): 235–8. PMID 1487235. 

扩展阅读

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