SNAPC3

小核RNA激活蛋白复合体，多肽3，50千道尔顿
Small nuclear RNA activating complex, polypeptide 3, 50kDa
小核RNA激活蛋白复合体，多肽3，50千道尔顿; Small nuclear RNA activating complex, polypeptide 3, 50kDa
标识
代号	SNAPC3; PTFbeta; SNAP50
扩展标识	遗传学：602348 鼠基因：1916338 同源基因：31130 GeneCards: SNAPC3 Gene
基因本体论描述
分子功能	· DNA binding;
细胞成分	· nucleus; · nucleoplasm;
生物过程	· regulation of transcription, DNA-dependent; · transcription from RNA polymerase II promoter; · transcription from RNA polymerase III promoter; · snRNA transcription; · gene expression;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	6619
Ensembl	ENSG00000164975
UniProt	Q92966
mRNA序列	NM_001039697
蛋白序列	NP_001034786
基因位置	Chr 9:; 15.42 – 15.47 Mb
PubMed查询	[1]
	查; 论; 编;

snRNA激活蛋白复合体第三亚基（英語：snRNA-activating protein complex subunit 3）是一个由人类基因SNAPC3编码的蛋白质^[1]^[2]。

相互作用

SNAPC3能与SNAPC1^[3]^[4]和视网膜母细胞瘤蛋白^[5]发生相互作用。

参考文献

^ Henry RW, Ma B, Sadowski CL, Kobayashi R, Hernandez N. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. EMBO J. February 1997, 15 (24): 7129–36. PMC 452539 . PMID 9003788.
^ Entrez Gene: SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa.
^ Henry, R W; Ma B, Sadowski C L, Kobayashi R, Hernandez N. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. EMBO J. (ENGLAND). Dec 1996, 15 (24): 7129–36. ISSN 0261-4189. PMC 452539 . PMID 9003788.
^ Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200.
^ Hirsch, H A; Gu L, Henry R W. The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression. Mol. Cell. Biol. (UNITED STATES). Dec 2000, 20 (24): 9182–91. ISSN 0270-7306. PMC 102176 . PMID 11094070. doi:10.1128/MCB.20.24.9182-9191.2000.

延伸阅读

Bagramian ER, Bogdanova EA, Krymskaia ML, Sokovykh SI. [Diagnostic importance of determining 17-ketosteroids in gynecology]. Akusherstvo i ginekologiia. 1977, (2): 65–7. PMID 900378.
Henry RW, Sadowski CL, Kobayashi R, Hernandez N. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.. Nature. 1995, 374 (6523): 653–6. PMID 7715707. doi:10.1038/374653a0.
Bai L, Wang Z, Yoon JB, Roeder RG. Cloning and characterization of the beta subunit of human proximal sequence element-binding transcription factor and its involvement in transcription of small nuclear RNA genes by RNA polymerases II and III.. Mol. Cell. Biol. 1996, 16 (10): 5419–26. PMC 231541 . PMID 8816454.
Ma B, Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc.. J. Biol. Chem. 2001, 276 (7): 5027–35. PMID 11056176. doi:10.1074/jbc.M009301200.
Hirsch HA, Gu L, Henry RW. The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.. Mol. Cell. Biol. 2001, 20 (24): 9182–91. PMC 102176 . PMID 11094070. doi:10.1128/MCB.20.24.9182-9191.2000.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hinkley CS, Hirsch HA, Gu L; et al. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition.. J. Biol. Chem. 2003, 278 (20): 18649–57. PMID 12621023. doi:10.1074/jbc.M204247200.
Humphray SJ, Oliver K, Hunt AR; et al. DNA sequence and analysis of human chromosome 9.. Nature. 2004, 429 (6990): 369–74. PMC 2734081 . PMID 15164053. doi:10.1038/nature02465.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, Hao T; et al. Towards a proteome-scale map of the human protein-protein interaction network.. Nature. 2005, 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Jawdekar GW, Hanzlowsky A, Hovde SL; et al. The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNAPC.. J. Biol. Chem. 2006, 281 (41): 31050–60. PMID 16901896. doi:10.1074/jbc.M603810200.

[pmid9003788-1] Henry RW, Ma B, Sadowski CL, Kobayashi R, Hernandez N. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. EMBO J. February 1997, 15 (24): 7129–36. PMC 452539 . PMID 9003788.

[entrez-2] Entrez Gene: SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa.

[pmid9003788_1-3] Henry, R W; Ma B, Sadowski C L, Kobayashi R, Hernandez N. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc. EMBO J. (ENGLAND). Dec 1996, 15 (24): 7129–36. ISSN 0261-4189. PMC 452539 . PMID 9003788.

[pmid11056176-4] Ma, B; Hernandez N. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. J. Biol. Chem. (United States). February 2001, 276 (7): 5027–35. ISSN 0021-9258. PMID 11056176. doi:10.1074/jbc.M009301200.

[pmid11094070-5] Hirsch, H A; Gu L, Henry R W. The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression. Mol. Cell. Biol. (UNITED STATES). Dec 2000, 20 (24): 9182–91. ISSN 0270-7306. PMC 102176 . PMID 11094070. doi:10.1128/MCB.20.24.9182-9191.2000.

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