MKL1
MKL/megakaryoblastic leukemia 1(巨核细胞白血病)是一种由人类基因 MKL1 编码的蛋白质。[1][2][3][4]
此基因编码的蛋白能与转录因子心肌素(英語:myocardin,一种调控平滑肌细胞分化的关键转录因子)相互作用。此蛋白主要存在于细胞核中,帮助信号从细胞质到细胞核的转导。在一个特异的染色体易位中,此基因会与1号染色体上的RNA结合基序蛋白15基因融合,这一易位与急性巨核细胞白血病相关。[4]
参考文献
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- ^ Sasazuki T, Sawada T, Sakon S, Kitamura T, Kishi T, Okazaki T, Katano M, Tanaka M, Watanabe M, Yagita H, Okumura K, Nakano H. Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. J Biol Chem. Aug 2002, 277 (32): 28853–60. PMID 12019265. doi:10.1074/jbc.M203190200.
- ^ Du KL, Chen M, Li J, Lepore JJ, Mericko P, Parmacek MS. Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals and induces smooth muscle cell differentiation from undifferentiated embryonic stem cells. J Biol Chem. Apr 2004, 279 (17): 17578–86. PMID 14970199. doi:10.1074/jbc.M400961200.
- ^ 4.0 4.1 Entrez Gene: MKL1 megakaryoblastic leukemia (translocation) 1.
延伸阅读
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