AR-R17779

AR-R17779
	IUPAC名; (2S)-4′-Azaspiro[bicyclo[2.2.2]octane-2,5′-[1,3]oxazolidin]-2′-one
别名	(−)-Spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one]
识别
CAS号	178419-47-1
PubChem	5310971
ChemSpider	4470515
SMILES	O=C3O[C@]1(CN2CCC1CC2)CN3;
InChI	1/C9H14N2O2/c12-8-10-5-9(13-8)6-11-3-1-7(9)2-4-11/h7H,1-6H2,(H,10,12)/t9-/m0/s1;
ChEBI	CHEBI:420311
性质
化学式	C9H14N2O2
摩尔质量	182.22 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参考文献

^ Mullen, G.; Napier, A.; Balestra, M.; Decory, T.; Hale, G.; Macor, J.; Mack, R.; Loch, J.; Wu, E.; Kover, A.; Verhoest, P.; Sampognaro, A.; Phillips, E.; Zhu, Y.; Murray, R.; Griffith, R.; Blosser, J.; Gurley, D.; Machulskis, A.; Zongrone, J.; Rosen, A.; Gordon, J. (−)-Spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the α7 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry. 2000, 43 (22): 4045–4050. PMID 11063601. doi:10.1021/jm000249r.
^ Macor, J.; Mullen, G.; Verhoest, P.; Sampognaro, A.; Shepardson, B.; Mack, R. A chiral synthesis of (−)-spiro[1-azabicyclo[2.2.2]octane-3,5′-oxazolidin-2′-one]: A conformationally restricted analogue of acetylcholine that is a potent and selective α7 nicotinic receptor agonist. The Journal of Organic Chemistry. 2004, 69 (19): 6493–6495. PMID 15357617. doi:10.1021/jo049404q.

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