3-羟基吡啶-2-甲酸

3-羟基吡啶-2-甲酸
	IUPAC名; 3-Hydroxypyridine-2-carboxylic acid
别名	3-Hydroxypicolinic acid; 3-Hydroxy-2-pyridinecarboxylic acid
识别
CAS号	874-24-8
PubChem	13401
ChemSpider	12827
SMILES	C1=CC(=C(N=C1)C(=O)O)O;
InChI	1/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10);
InChIKey	BRARRAHGNDUELT-UHFFFAOYAC
ChEBI	63432
性质
化学式	C6H5NO3
摩尔质量	139.109 g·mol⁻¹
外观	浅黄色针状晶体
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

3-羟基吡啶-2-甲酸是一种有机化合物，化学式为C₆H₅NO₃，它可通过3-氨基吡啶-2-甲酸的重氮化反应制得，它在214~215 °C分解。^[1]它和金属盐反应，可以得到相应的配合物。^[2]^[3]它和甲醇在硫酸存在下回流反应，可以得到3-羟基吡啶-2-甲酸甲酯。^[4]

参考文献

^ Lewis R. Fibel, Paul E. Spoerri. The Synthesis and Investigation of Pyridine and Pyrazine Analogs of Salicylates 1,2. Journal of the American Chemical Society. 1948-11, 70 (11): 3908–3911 [2022-03-09]. ISSN 0002-7863. doi:10.1021/ja01191a113. （原始内容存档于2022-03-09）（英语）.
^ Boris-Marko Kukovec, Pedro D.Vaz, Maria José Calhorda, Zora Popović. Structural preferences and isomerism in nickel(II) and copper(II) complexes with 3-hydroxypicolinic acid. Polyhedron. 2012-05, 39 (1): 66–75 [2022-03-09]. doi:10.1016/j.poly.2012.03.040. （原始内容存档于2020-02-19）（英语）.
^ Tanja Koleša-Dobravc, Keiichi Maejima, Yutaka Yoshikawa, Anton Meden, Hiroyuki Yasui, Franc Perdih. Bis(picolinato) complexes of vanadium and zinc as potential antidiabetic agents: synthesis, structural elucidation and in vitro insulin-mimetic activity study. New Journal of Chemistry. 2018, 42 (5): 3619–3632 [2022-03-09]. ISSN 1144-0546. doi:10.1039/C7NJ04189F （英语）.
^ Tatiana N. Pashirova, Anissa Braïki, Irina V. Zueva, Konstantin A. Petrov, Vasily M. Babaev, Evgenia A. Burilova, Darya A. Samarkina, Ildar Kh. Rizvanov, Eliana B. Souto, Ludovic Jean, Pierre-Yves Renard, Patrick Masson, Lucia Ya. Zakharova, Oleg G. Sinyashin. Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection. Journal of Controlled Release. 2018-11, 290: 102–111 [2022-03-09]. doi:10.1016/j.jconrel.2018.10.010. （原始内容存档于2021-03-08）（英语）.

[1] Lewis R. Fibel, Paul E. Spoerri. The Synthesis and Investigation of Pyridine and Pyrazine Analogs of Salicylates 1,2. Journal of the American Chemical Society. 1948-11, 70 (11): 3908–3911 [2022-03-09]. ISSN 0002-7863. doi:10.1021/ja01191a113. （原始内容存档于2022-03-09）（英语）.

[2] Boris-Marko Kukovec, Pedro D.Vaz, Maria José Calhorda, Zora Popović. Structural preferences and isomerism in nickel(II) and copper(II) complexes with 3-hydroxypicolinic acid. Polyhedron. 2012-05, 39 (1): 66–75 [2022-03-09]. doi:10.1016/j.poly.2012.03.040. （原始内容存档于2020-02-19）（英语）.

[3] Tanja Koleša-Dobravc, Keiichi Maejima, Yutaka Yoshikawa, Anton Meden, Hiroyuki Yasui, Franc Perdih. Bis(picolinato) complexes of vanadium and zinc as potential antidiabetic agents: synthesis, structural elucidation and in vitro insulin-mimetic activity study. New Journal of Chemistry. 2018, 42 (5): 3619–3632 [2022-03-09]. ISSN 1144-0546. doi:10.1039/C7NJ04189F （英语）.

[4] Tatiana N. Pashirova, Anissa Braïki, Irina V. Zueva, Konstantin A. Petrov, Vasily M. Babaev, Evgenia A. Burilova, Darya A. Samarkina, Ildar Kh. Rizvanov, Eliana B. Souto, Ludovic Jean, Pierre-Yves Renard, Patrick Masson, Lucia Ya. Zakharova, Oleg G. Sinyashin. Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection. Journal of Controlled Release. 2018-11, 290: 102–111 [2022-03-09]. doi:10.1016/j.jconrel.2018.10.010. （原始内容存档于2021-03-08）（英语）.

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