阿莫奈韋 商品名 Amenalief 其他名稱 ASP-2151, ASP2151 ATC碼 法律規範
N -(2,6-Dimethylphenyl)-N -[2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl]-1,1-dioxothiane-4-carboxamide
CAS號 841301-32-4 PubChem CID DrugBank ChemSpider UNII KEGG CompTox Dashboard (EPA ) 化學式 C 24 H 26 N 4 O 5 S 摩爾質量 482.56 g·mol−1 3D模型(JSmol )
Cc1cccc(C)c1N(CC(=O)Nc1ccc(-c2ncon2)cc1)C(=O)C1CCS(=O)(=O)CC1
InChI=1S/C24H26N4O5S/c1-16-4-3-5-17(2)22(16)28(24(30)19-10-12-34(31,32)13-11-19)14-21(29)26-20-8-6-18(7-9-20)23-25-15-33-27-23/h3-9,15,19H,10-14H2,1-2H3,(H,26,29)
Key:MNHNIVNAFBSLLX-UHFFFAOYSA-N
阿莫奈韋 (INN :amenamevir)是一種用於治療帶狀疱疹 的抗病毒藥物 。
它充當帶狀疱疹病毒解旋酶-引物酶複合物 的抑制劑。[ 1] [ 2] 阿莫奈韋於2017年在日本獲批用於治療帶狀疱疹。[ 3]
參考資料
^ Kawashima M, Nemoto O, Honda M, Watanabe D, Nakayama J, Imafuku S, et al. Amenamevir, a novel helicase-primase inhibitor, for treatment of herpes zoster: A randomized, double-blind, valaciclovir-controlled phase 3 study . The Journal of Dermatology. November 2017, 44 (11): 1219–1227. PMC 5697646 . PMID 28681394 . doi:10.1111/1346-8138.13948 .
^ Yajima M, Yamada H, Takemoto M, Daikoku T, Yoshida Y, Long T, et al. Profile of anti-herpetic action of ASP2151 (amenamevir) as a helicase-primase inhibitor. Antiviral Research. March 2017, 139 : 95–101. PMID 28027917 . S2CID 43813287 . doi:10.1016/j.antiviral.2016.12.008 .
^ Maruho Receives Manufacturing and Marketing Approval for Anti-Herpes Virus Agent "Amenalief® Tab. 200mg" in Japan (新聞稿). evaluategroup.com. July 3, 2017.
巴爾的摩分類
B肝病毒 (VII)廣譜藥物/一般型
† 臨床研究中. # = WHO基本藥物