噻二唑

噻二唑是唑類化合物的一個亞族，噻二唑的名稱源自漢奇-威德曼命名法。從結構上看，它們是含有1個硫原子和2個氮原子的五元雜環化合物。它們由於兩個雙鍵和硫孤對而成為芳香環。根據雜原子的相對位置，存在四種可能的結構；這些形式不會相互轉化，因此是結構異構體而不是互變異構體。這些化合物本身很少被合成並且沒有特殊的應用，然而，以它們作為結構基序的化合物在藥理學中相當常見。 1,3,4-噻二唑是最常見的，出現在頭孢唑啉和乙醯唑胺等藥物中。^[1]^[2]^[3]

參考資料

^ Hu, Yang; Li, Cui-Yun; Wang, Xiao-Ming; Yang, Yong-Hua; Zhu, Hai-Liang. 1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry. Chemical Reviews. 2014, 114 (10): 5572–5610. ISSN 0009-2665. PMID 24716666. doi:10.1021/cr400131u.
^ Jain, Abhishek Kumar; Sharma, Simant; Vaidya, Ankur; Ravichandran, Veerasamy; Agrawal, Ram Kishore. 1,3,4-Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities. Chemical Biology & Drug Design. 2013, 81 (5): 557–576. ISSN 1747-0277. PMID 23452185. doi:10.1111/cbdd.12125 .
^ Wim Dehaen; Vasiliy A. Bakulev; Edward C. Taylor; Jonathan A. Ellman. The Chemistry of Heterocyclic Compounds, The Chemistry of 1,2,3-Thiadiazoles. John Wiley & Sons. 27 April 2004: 5–. ISBN 978-0-471-65691-3.

[HuLi2014-1] Hu, Yang; Li, Cui-Yun; Wang, Xiao-Ming; Yang, Yong-Hua; Zhu, Hai-Liang. 1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry. Chemical Reviews. 2014, 114 (10): 5572–5610. ISSN 0009-2665. PMID 24716666. doi:10.1021/cr400131u.

[JainSharma2013-2] Jain, Abhishek Kumar; Sharma, Simant; Vaidya, Ankur; Ravichandran, Veerasamy; Agrawal, Ram Kishore. 1,3,4-Thiadiazole and its Derivatives: A Review on Recent Progress in Biological Activities. Chemical Biology & Drug Design. 2013, 81 (5): 557–576. ISSN 1747-0277. PMID 23452185. doi:10.1111/cbdd.12125 .

[DehaenBakulev2004-3] Wim Dehaen; Vasiliy A. Bakulev; Edward C. Taylor; Jonathan A. Ellman. The Chemistry of Heterocyclic Compounds, The Chemistry of 1,2,3-Thiadiazoles. John Wiley & Sons. 27 April 2004: 5–. ISBN 978-0-471-65691-3.

[1]

[2]

[3]