B4GALT5

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
尿苷二磷酸半乳糖β，N-乙酰葡萄糖胺β1,4-半乳糖基转移酶，多肽5
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5; 尿苷二磷酸半乳糖β，N-乙酰葡萄糖胺β1,4-半乳糖基转移酶，多肽5
标识
代号	B4GALT5; B4Gal-T5; BETA4-GALT-IV; beta4Gal-T5; beta4GalT-V; gt-V
扩展标识	遗传学：604016 鼠基因：1927169 同源基因：3507 GeneCards: B4GALT5 Gene
EC编号	2.4.1.38
基因本体论描述
分子功能	· galactosyltransferase activity; · metal ion binding;
细胞成分	· Golgi membrane; · integral to membrane; · Golgi cisterna membrane;
生物过程	· carbohydrate metabolic process; · O-glycan processing; · keratan sulfate biosynthetic process; · protein N-linked glycosylation via asparagine; · glycosaminoglycan metabolic process; · keratan sulfate metabolic process; · post-translational protein modification; · cellular protein metabolic process; · small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	9334
Ensembl	ENSG00000158470
UniProt	O43286
mRNA序列	NM_004776
蛋白序列	NP_004767
基因位置	Chr 20:; 48.25 – 48.33 Mb
PubMed查询	[1]
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β-1,4-半乳糖基转移酶5（英语：Beta-1,4-galactosyltransferase 5）是一种由人类基因B4GALT5 所表达的酶^[1]^[2]^[3]。

参考文献

^ Lo NW, Shaper JH, Pevsner J, Shaper NL. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. Aug 1998, 8 (5): 517–26. PMID 9597550. doi:10.1093/glycob/8.5.517.
^ Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I. Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase. Proc Natl Acad Sci U S A. Feb 1998, 95 (2): 472–7. PMC 18444 . PMID 9435216. doi:10.1073/pnas.95.2.472.
^ Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5.

延伸阅读

Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim. Biophys. Acta. 2000, 1473 (1): 35–53. PMID 10580128. doi:10.1016/S0304-4165(99)00168-3.
Sato T, Aoki N, Matsuda T, Furukawa K. Differential effect of alpha-lactalbumin on beta-1,4-galactosyltransferase IV activities. Biochem. Biophys. Res. Commun. 1998, 244 (3): 637–41. PMID 9535717. doi:10.1006/bbrc.1998.8327.
Deloukas P, Matthews LH, Ashurst J; et al. The DNA sequence and comparative analysis of human chromosome 20. Nature. 2002, 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a.
Jia L, Young MF, Powell J; et al. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Genomics. 2002, 79 (1): 7–17. PMID 11827452. doi:10.1006/geno.2001.6683.
Xu S, Zhang S, Chen C; et al. Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line. J. Exp. Clin. Cancer Res. 2003, 21 (3): 409–14. PMID 12385586.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T; et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Sato T, Furukawa K. Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1. J. Biol. Chem. 2004, 279 (38): 39574–83. PMID 15263012. doi:10.1074/jbc.M405805200.
Gerhard DS, Wagner L, Feingold EA; et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Jiang J, Chen X, Shen J; et al. Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma. J. Biol. Chem. 2006, 281 (14): 9482–9. PMID 16461357. doi:10.1074/jbc.M504489200.
Sato T, Furukawa K. Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells. J. Biol. Chem. 2007, 282 (38): 27702–12. PMID 17656364. doi:10.1074/jbc.M611862200.
Kitayama K, Hayashida Y, Nishida K, Akama TO. Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans. J. Biol. Chem. 2007, 282 (41): 30085–96. PMID 17690104. doi:10.1074/jbc.M703695200.

[pmid9597550-1] Lo NW, Shaper JH, Pevsner J, Shaper NL. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. Aug 1998, 8 (5): 517–26. PMID 9597550. doi:10.1093/glycob/8.5.517.

[pmid9435216-2] Sato T, Furukawa K, Bakker H, Van den Eijnden DH, Van Die I. Molecular cloning of a human cDNA encoding β-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc β-1,4-galactosyltransferase. Proc Natl Acad Sci U S A. Feb 1998, 95 (2): 472–7. PMC 18444 . PMID 9435216. doi:10.1073/pnas.95.2.472.

[entrez-3] Entrez Gene: B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5.

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[2]

[3]