Fel d 1

Fel d 1
	存在于猫唾液中的主要过敏原——Fel d 1二聚体的晶体结构
识别
符号	CH2
替换符号	Fel d I, AG4, Allergen Cat-1
Entrez	677879
PDB	1PUO
UniProt	P30440
其他资料

Fel d 1（Felis domesticus allergen 1^[2]）是猫的一种蛋白质，由CH2基因编码^[3]^[4]。Fel d 1主要在猫的唾液腺和皮脂腺中分泌，是存在于猫身上的主要过敏原。目前尚未清楚这种蛋白质在动物体内的作用，但它能引起敏感人群对lgG或lgE作出过敏反应或哮喘反应。

降低家居Fed d 1含量的可行方法有移开柔软表面（地毯）、经常洗床单、洗高效滤网和为猫洗澡。Fel d 1是一种特别粘的蛋白质，已被证明能粘在衣物和人的毛发中，而且在猫从未出现过的地方也能检测得到。

猫平均每天产生2-7微克的Fel d 1。研究也发现未被阉割的公猫的Fel d 1的产量较被阉割的公猫多，这也导致一个假设的产生，假设认为Fel d 1是由睾酮激素调控的。被阉割的公猫的Fed d 1产量和母猫相近，而未被阉割的母猫的Fel d 1的产量也与被阉割的母猫的相近。尽管母猫和被阉割的公猫的Fel d 1产量低，但也足以引发敏感人群的过敏反应。

Fel d 1是一种分子量有18 kDa的异源二聚体蛋白质^[2]。

参考文献

^ PDB 1PUO; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G. The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. J. Biol. Chem. September 2003, 278 (39): 37730–5. PMID 12851385. doi:10.1074/jbc.M304740200.
^ ^2.0 ^2.1 Natural Fel d 1 (PDF). INDOOR Biotechnologies. [2011-07-13]. ^{[永久失效链接]}
^ Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC. Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. November 1991, 88 (21): 9690–4. PMC 52784 . PMID 1946388.
^ Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL. Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat. Gene. April 1992, 113 (2): 263–8. PMID 1572548.

参见

[pmid12851385-1] PDB 1PUO; Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G. The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family. J. Biol. Chem. September 2003, 278 (39): 37730–5. PMID 12851385. doi:10.1074/jbc.M304740200.

[INDOOR-2] 2.0 ^2.1 Natural Fel d 1 (PDF). INDOOR Biotechnologies. [2011-07-13]. ^{[永久失效链接]}

[pmid1946388-3] Morgenstern JP, Griffith IJ, Brauer AW, Rogers BL, Bond JF, Chapman MD, Kuo MC. Amino acid sequence of Fel dI, the major allergen of the domestic cat: protein sequence analysis and cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. November 1991, 88 (21): 9690–4. PMC 52784 . PMID 1946388.

[pmid1572548-4] Griffith IJ, Craig S, Pollock J, Yu XB, Morgenstern JP, Rogers BL. Expression and genomic structure of the genes encoding FdI, the major allergen from the domestic cat. Gene. April 1992, 113 (2): 263–8. PMID 1572548.

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