黑素皮质素受体
黑素皮质素受体（英语：Melanocortin receptor，缩写MCR）是七跨膜的G蛋白偶联受体中视紫质家族的一员，在人类基因组包括五个成员[1]，各自对不同黑素皮质素有不同亲和活性[2][3][4]：
- MC1R，MC1R与遗传色素沉着有关。
- MC2R，MC2R也被称为ACTH受体，能特异性结合促肾上腺皮质激素（ACTH）。
- MC3R，MC3R
- MC4R，MC4R缺陷是常染色体显性肥胖症的一个原因，占所有早发性肥胖病例的6%[5]。
- MC5R，MC5R。
参考文献
- ^ Melanocortins and the Melanocortin Receptor. [2007-03-14]. （原始内容存档于2007-04-11）.
- ^ Voisey J, Carroll L, van Daal A. Melanocortins and their receptors and antagonists. Current Drug Targets. October 2003, 4 (7): 586–97. PMID 14535656. doi:10.2174/1389450033490858.
- ^ Hadley ME, Dorr RT. Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. April 2006, 27 (4): 921–30. PMID 16412534. doi:10.1016/j.peptides.2005.01.029.
- ^ Dores RM. Adrenocorticotropic hormone, melanocyte-stimulating hormone, and the melanocortin receptors: revisiting the work of Robert Schwyzer: a thirty-year retrospective. Annals of the New York Academy of Sciences. April 2009, 1163 (1): 93–100. PMID 19456331. doi:10.1111/j.1749-6632.2009.04434.x.
- ^ Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. 2003, 348 (12): 1085–95. PMID 12646665. doi:10.1056/NEJMoa022050.
外部链接
- Melanocortin Receptors. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. [2020-12-16]. （原始内容存档于2021-01-30）.
- 医学主题词表（MeSH）：Melanocortin+Receptors
- Calculated spatial position of melanocortin-4 receptor in the lipid bilayer, inactive state with antagonist （页面存档备份，存于互联网档案馆） and active state with agonist （页面存档备份，存于互联网档案馆）