Ro 5-3663
| Ro 5-3663 | |
|---|---|
| |
| 別名 | 5-甲基-1H-苯並[e][1,4]二氮雜環庚三烯-2(3H)-酮 |
| 識別 | |
| CAS號 | 70656-87-0 
|
| PubChem | 135432558 |
| SMILES |
|
| 性質 | |
| 化學式 | C10H10N2O |
| 摩爾質量 | 174.2 g·mol−1 |
| 外觀 | 白色固體[1] |
| 熔點 | 178~181 °C[1] |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
Ro 5-3663是一種有機化合物，化學式為C10H10N2O，其化學名為1,3-二氫-5-甲基-2H-1,4-苯二氮䓬-2-酮。它可以2'-氨基苯乙酮和N-叔丁氧羰基甘氨酸（或N-芴甲氧羰基甘氨酸[1]）為原料反應製得。[2]它和苯甲醇（或異丙醇）、三丁基膦、DIAD在三氯甲烷中反應，可以得到1-苄基-Ro 5-3663或1-異丙基-Ro 5-3663。[1]
參考文獻
- ^ 1.0 1.1 1.2 1.3 Kwan-Young Jung; Steven Fletcher. Fine-tuning the chemo- and regioselective alkylation of 1,4-benzodiazepines: further applications of the Mitsunobu reaction. MedChemComm, 2012. doi:10.1039/C2MD20123B.
- ^ Romain Siegrist, Davide Pozzi, Gaël Jacob, Caterina Torrisi, Kilian Colas, Bertrand Braibant, Jacques Mawet, Thomas Pfeifer, Ruben de Kanter, Catherine Roch, Melanie Kessler, Richard Moon, Olivier Corminboeuf, Olivier Bezençon. Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers. Journal of Medicinal Chemistry (2016), 59 (23), 10661-10675. doi:10.1021/acs.jmedchem.6b01356.