組織蛋白酶W

組織蛋白酶W
識別號
別名	CTSW；, LYPN, cathepsin W
外部ID	OMIM：602364 MGI：1338045 HomoloGene：37471 GeneCards：CTSW
基因位置（人類）
染色體	11號染色體
終止	65,883,741 bp
基因位置（小鼠）
染色體	小鼠19號染色體
終止	5,518,535 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• 肽酶活性; • cysteine-type endopeptidase activity; • 半胱氨酸型肽酶活性; • 水解酶活性;
細胞組分	• 溶酶體; • 膜; • platelet dense granule lumen; • 細胞外區域; • 細胞外空間; • 內質網;
生物學過程	• proteolysis involved in cellular protein catabolic process; • 免疫反應; • 蛋白酶解; • platelet degranulation;
	Sources:Amigo / QuickGO
直系同源
	1521
	13041
	ENSG00000172543
	ENSMUSG00000024910
	P56202
	P56203
	NM_001335
	NM_009985
	NP_001326
	NP_034115
	維基數據
檢視/編輯人類	檢視/編輯小鼠

組織蛋白酶W（英語：Cathepsin W）是一種在人體中由CTSW基因編碼的蛋白質。^[5]^[6]^[7]

該基因編碼的蛋白質是半胱氨酸組織蛋白酶肽酶C1家族的成員，是一種半胱氨酸蛋白酶組織蛋白酶，可能在T細胞溶細胞活性的機制或調節中具有特定功能。編碼的蛋白質被發現與自然殺傷細胞和細胞毒性T細胞的內質網內的細胞膜有關。該基因的表達被白血球介素2上調。^[7]

參見

組織蛋白酶

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000024910 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Linnevers C, Smeekens SP, Brömme D. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. FEBS Lett. May 1997, 405 (3): 253–9. PMID 9108299. S2CID 45420314. doi:10.1016/S0014-5793(97)00118-X .
^ Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D. Genomic structure, chromosomal localization, and expression of human cathepsin W. Biochem Biophys Res Commun. Aug 1998, 248 (2): 255–61. PMID 9675123. doi:10.1006/bbrc.1998.8954.
^ ^7.0 ^7.1 Entrez Gene: CTSW cathepsin W.

閱讀

Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Meinhardt C, Peitz U, Treiber G, et al. Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene.. Biochem. Biophys. Res. Commun. 2004, 321 (4): 975–80. PMID 15358123. doi:10.1016/j.bbrc.2004.07.056.
Zhang Z, Henzel WJ. Signal peptide prediction based on analysis of experimentally verified cleavage sites.. Protein Sci. 2005, 13 (10): 2819–24. PMC 2286551 . PMID 15340161. doi:10.1110/ps.04682504.
Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Buhling F, Kellner U, Guenther D, et al. Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract.. Biol. Chem. 2003, 383 (7–8): 1285–9. PMID 12437118. S2CID 23389714. doi:10.1515/BC.2002.144.
Wex T, Bühling F, Wex H, et al. Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum.. J. Immunol. 2001, 167 (4): 2172–8. PMID 11490002. doi:10.4049/jimmunol.167.4.2172 .
Wex T, Levy B, Wex H, Brömme D. Human cathepsins W and F form a new subgroup of cathepsins that is evolutionary separated from the cathepsin B- and L-like cysteine proteases.. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 2000, 477: 271–80. ISBN 0-306-46383-0. PMID 10849754. doi:10.1007/0-306-46826-3_29.
Brinkworth RI, Tort JF, Brindley PJ, Dalton JP. Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes.. Int. J. Biochem. Cell Biol. 2000, 32 (3): 373–84. PMID 10716634. doi:10.1016/S1357-2725(99)00129-6.
Wex T, Levy B, Wex H, Brömme D. Human cathepsins F and W: A new subgroup of cathepsins.. Biochem. Biophys. Res. Commun. 1999, 259 (2): 401–7. PMID 10362521. doi:10.1006/bbrc.1999.0700.
Brown J, Matutes E, Singleton A, et al. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase.. Leukemia. 1998, 12 (11): 1771–81. PMID 9823953. doi:10.1038/sj.leu.2401164 .

外部連結

The MEROPS online database for peptidases and their inhibitors: C01.037^{[失效連結]}

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000172543 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000024910 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9108299-5] Linnevers C, Smeekens SP, Brömme D. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. FEBS Lett. May 1997, 405 (3): 253–9. PMID 9108299. S2CID 45420314. doi:10.1016/S0014-5793(97)00118-X .

[pmid9675123-6] Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D. Genomic structure, chromosomal localization, and expression of human cathepsin W. Biochem Biophys Res Commun. Aug 1998, 248 (2): 255–61. PMID 9675123. doi:10.1006/bbrc.1998.8954.

[entrez-7] 7.0 ^7.1 Entrez Gene: CTSW cathepsin W.

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[2]

[3]

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[5]

[6]

[7]

閱論編蛋白酶類：半胱氨酸蛋白酶類（EC 3.4.22)
胱天蛋白酶	胱天蛋白酶1 胱天蛋白酶2 胱天蛋白酶3 胱天蛋白酶4 胱天蛋白酶5 胱天蛋白酶6 胱天蛋白酶7 胱天蛋白酶8 胱天蛋白酶9 胱天蛋白酶10 胱天蛋白酶11 胱天蛋白酶12 胱天蛋白酶13 胱天蛋白酶14
來自果實	木瓜蛋白酶無花果蛋白酶（英語：Ficain）鳳梨蛋白酶獼猴桃蛋白酶
鈣蛋白酶	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
組織蛋白酶	B C F H K L1/L2 O S T W Z
其它	梭菌蛋白酶癌性促凝物質分離酶（英語：Separase） Autophagin Cruzipain 3C樣蛋白酶
EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3（英語：Template:Ligases CO CS and CN）/4/5-6

閱論編酶
活性	活性位點結合位點催化三聯體負氧離子洞酶催化混雜（英語：Enzyme promiscuity）催化最適酶（英語：Catalytically perfect enzyme）輔因子輔酶酶促反應
調節	變構調節協同性（英語：Cooperativity）酶抑制劑酶活化劑
分類	EC編號蛋白質超家族蛋白質家族酶列表
動力學	酶動力學伊迪-霍夫斯蒂圖（英語：Eadie–Hofstee diagram）哈尼斯-伍爾夫圖（英語：Hanes–Woolf plot）雙倒數圖米氏動力學
類型	EC1 氧化還原酶（列表（英語：List of EC numbers (EC 1)）） EC2 轉移酶（列表（英語：List of EC numbers (EC 2)）） EC3 水解酶（列表（英語：List of EC numbers (EC 3)）） EC4 裂解酶（列表（英語：List of EC numbers (EC 4)）） EC5 異構酶（列表（英語：List of EC numbers (EC 5)）） EC6 連接酶（列表（英語：List of EC numbers (EC 6)）） EC7 移位酶（英語：Translocase）（列表（英語：List of EC numbers (EC 7)））