白血球介素-21

IL21
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	2OQP、3TGX
識別號
別名	IL21；, CVID11, IL-21, Za11, interleukin 21
外部ID	OMIM：605384 MGI：1890474 HomoloGene：11032 GeneCards：IL21
基因位置（人類）
染色體	4號染色體
終止	122,621,066 bp
基因位置（小鼠）
染色體	小鼠3號染色體
終止	37,286,785 bp
RNA表達模式
	查閱更多表達數據
基因本體
分子功能	• 細胞因子活性; • interleukin-2 receptor binding; • 細胞因子受體結合;
細胞組分	• 胞內; • 細胞外空間; • 細胞外區域;
生物學過程	• positive regulation of inflammatory response; • positive regulation of cytokine production; • cell maturation; • positive regulation of B cell proliferation; • positive regulation of tissue remodeling; • positive regulation of T cell proliferation; • 免疫反應; • positive regulation of cell population proliferation; • positive regulation of interleukin-17 production; • positive regulation of natural killer cell mediated cytotoxicity; • 信號轉導; • tyrosine phosphorylation of STAT protein; • positive regulation of tyrosine phosphorylation of STAT protein; • regulation of signaling receptor activity; • interleukin-21-mediated signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	59067
	60505
	ENSG00000138684
	ENSMUSG00000027718
	Q9HBE4
	Q9ES17
	NM_021803; NM_001207006
	NM_021782; NM_001291041
	NP_001193935; NP_068575
	NP_001277970; NP_068554
	維基數據
檢視/編輯人類	檢視/編輯小鼠

白血球介素-21（英語：Interleukin-21，縮寫IL-21）是一種細胞因子，由人類基因 IL21 編碼^[5]，與細胞表面的白血球介素-21受體結合發揮作用^[6]^[7]。

參考資料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000138684 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000027718 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: IL21 interleukin 21.
^ Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, Kramer J, Conklin D, Presnell SR, Berry J, Shiota F, Bort S, Hambly K, Mudri S, Clegg C, Moore M, Grant FJ, Lofton-Day C, Gilbert T, Rayond F, Ching A, Yao L, Smith D, Webster P, Whitmore T, Maurer M, Kaushansky K, Holly RD, Foster D. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. November 2000, 408 (6808): 57–63. Bibcode:2000Natur.408...57P. PMID 11081504. S2CID 4428126. doi:10.1038/35040504.
^ Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. Journal of Immunology. November 2007, 179 (9): 5886–96. PMID 17947662. doi:10.4049/jimmunol.179.9.5886 .