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癌症標誌物

維基百科,自由的百科全書

癌症標誌物又稱腫瘤標誌物,是由癌細胞直接產生或由非癌細胞經癌細胞誘導產生(人體對癌細胞的反應)的物質(生物標記[1]。癌症標誌物存在於人們的血液、尿液或組織中。對於腫瘤標誌物的檢測可對腫瘤存在、發病過程及預後作出判斷。每個腫瘤標誌物對應的癌症有所不同。腫瘤標誌物水平升高可能表明患有癌症,然而也可能有其他原因導致升高。

癌症標誌物可回答的問題:

  • 預後:這種癌症可能繼續生長?
  • 診斷:我患了何種癌症?
  • 預測:這種藥是針對我患癌症的最佳用藥嗎?
  • 藥效學:對我來說此藥的最佳用量是多少?
  • 復發:癌症會再次發作嗎?

常見的腫瘤標誌物

腫瘤標誌物 有關的癌症
Α-胎兒蛋白 (AFP) 生殖細胞瘤, 肝細胞癌[2]
CA 15-3 乳癌[3]
CA27.29 乳癌[4]
CA19-9 胰臟癌大腸癌胃腸道癌.[5]
CA-125 卵巢癌,[6]子宮內膜癌, 輸卵管瘤, 肺癌, 乳癌胃腸道癌.[7]子宮內膜異位症.[8]
降鈣素 甲狀腺髓質癌
Calretinin英語Calretinin 間皮瘤, 性腺間質腫瘤, adrenocortical carcinoma英語adrenocortical carcinoma, 滑膜肉瘤[2]
癌胚抗原 胃腸道癌, 子宮頸癌, 肺癌, 卵巢癌, 乳癌, urinary tract cancer[2]
CD34 hemangiopericytoma英語hemangiopericytoma/solitary fibrous tumor英語solitary fibrous tumor, 多形性脂肪瘤, 胃腸道基質腫瘤, dermatofibrosarcoma protuberans英語dermatofibrosarcoma protuberans[2]
CD99英語CD99MIC 2 尤文氏肉瘤, primitive neuroectodermal tumor英語primitive neuroectodermal tumor, hemangiopericytoma英語hemangiopericytoma/solitary fibrous tumor英語solitary fibrous tumor, 滑膜肉瘤, 淋巴瘤, 白血病, 性腺間質腫瘤[2]
CD117英語CD117 胃腸道基質腫瘤, mastocytosis英語mastocytosis, seminoma英語seminoma[2]
Chromogranin英語Chromogranin 神經內分泌腫瘤[2]
Chromosomes 3, 7, 17, and 9p21 膀胱癌[9]
Cytokeratin英語Cytokeratin (TPA, TPS, Cyfra21-1) 肉瘤[2]
Desmin英語Desmin smooth muscle sarcoma, 橫紋肌肉瘤, endometrial stromal sarcoma英語endometrial stromal sarcoma[2]
Epithelial membrane antigen英語Epithelial membrane antigen (EMA) meningioma英語meningioma肉瘤[2]
Factor VIII英語Factor VIII, CD31 FL1 vascular sarcoma[2]
Glial fibrillary acidic protein英語Glial fibrillary acidic protein (GFAP) 神經膠質瘤 (astrocytoma英語astrocytoma, ependymoma英語ependymoma)[2]
Gross cystic disease fluid protein (GCDFP-15) 乳癌, 卵巢癌, salivary gland cancer英語salivary gland cancer[2]
hPG80英語hPG80 乳癌, 卵巢癌, 前列腺癌, 腎癌, 大腸癌, 肝癌
HMB-45英語HMB-45 黑色素瘤, PEComa英語PEComa (例如 angiomyolipoma英語angiomyolipoma), clear cell adenocarcinoma英語clear cell adenocarcinoma, adrenocortical carcinoma英語adrenocortical carcinoma[2]
人絨毛膜促性腺激素 (hCG) 妊娠滋養細胞疾病, 生殖細胞瘤, 絨毛膜癌[2]
抗體 淋巴瘤, 白血病[2]
激活素與抑制素 性腺間質腫瘤, adrenocortical carcinoma英語adrenocortical carcinoma, hemangioblastoma英語hemangioblastoma[2]
角蛋白 , 肉瘤[2]
淋巴細胞 淋巴瘤, 白血病[2]
MART-1英語MART-1 (Melan-A) 黑色素瘤,adrenocortical carcinoma英語adrenocortical carcinomagonadal tumor[2]
Myo D1英語Myo D1 橫紋肌肉瘤, small, round, blue cell tumour英語small, round, blue cell tumour[2]
muscle-specific actin (MSA) myosarcoma英語myosarcoma (平滑肌肉瘤, 橫紋肌肉瘤)[2]
neurofilament英語neurofilament 神經內分泌腫瘤, 小細胞癌[2]
neuron-specific enolase英語neuron-specific enolase (NSE) 神經內分泌腫瘤, 小細胞癌, 乳癌[2]
placental alkaline phosphatase英語placental alkaline phosphatase (PLAP) seminoma英語seminoma, 無性細胞瘤, 胚胎性癌[2]
前列腺特異抗原 (PSA) 前列腺[2]
蛋白酪氨酸磷酸酶C型受體 (CD45) 淋巴瘤, 白血病, histiocytic sarcoma英語histiocytic sarcoma[2]
S100蛋白 黑色素瘤, 肉瘤 (neurosarcoma英語neurosarcoma, 脂肪瘤, chondrosarcoma英語chondrosarcoma), astrocytoma英語astrocytoma, 胃腸道基質腫瘤, salivary gland cancer英語salivary gland cancer, adenocarcinoma英語adenocarcinoma, histiocytic tumor (樹突狀細胞, 巨噬細胞)[2]
smooth muscle actin (SMA) 胃腸道基質腫瘤, 平滑肌肉瘤, PEComa英語PEComa[2]
突觸素 神經內分泌腫瘤[2]
胸苷激酶 淋巴瘤, 白血病, 肺癌, 前列腺癌
thyroglobulin英語thyroglobulin (Tg) 甲狀腺癌[2]
thyroid transcription factor-1英語thyroid transcription factor-1 (TTF-1) 甲狀腺癌, 肺癌[2]
Tumor M2-PK英語Tumor M2-PK 大腸癌,[10] 乳癌,[11][12] renal cell carcinoma英語renal cell carcinoma[13][14] 肺癌,[15][16] 胰臟癌,[17] 食道癌,[18] 胃癌,[18]子宮頸癌,[19] 卵巢癌,[20]
波形蛋白 肉瘤, renal cell carcinoma英語renal cell carcinoma, 子宮內膜癌, 肺癌, 淋巴瘤, 白血病, 黑色素瘤[2]

分子癌症標誌物

腫瘤類型 生物標誌物
乳腺 ER(雌激素受體)[21][22]
HER-2/neu[21][22]
結直腸 EGFR[21][22]
KRAS[21][23]
UGT1A1[21][23]
HER-2/neu[21]
胃腸道基質腫瘤 c-KIT[21][24]
白血病/淋巴瘤 CD20抗原[21][25]
CD30[21][26]
FIP1L1-PDGRFα[21][27]
PDGFR[21][28]
費城染色體(BCR/ABL)[21][29][30]
PML/RARα[21][31]
TPMT[21][32]
UGT1A1[21][33]
ALK[21][34][35]
EGFR[21][22]
KRAS[21][22]
黑色素瘤 BRAF[21][35]

生物標誌物的其它例子:

參考文獻

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