凝血酶
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凝血酶（英語：Thrombin，EC 3.4.21.5）是一種「胰蛋白酶樣」絲氨酸蛋白酶蛋白質，在人體中被F2基因所編碼[2][3]。在凝血作用第一級級聯反應中，凝血酶原（凝血因子Ⅱ）被蛋白水解性切除以生成凝血酶，級聯反應最終阻止了血液的繼續流失。凝血酶轉而作為一種絲氨酸蛋白酶以使可溶性的纖維蛋白原轉變為不溶性的纖維蛋白，同時催化其他許多與凝血相關的反應。
另見
參考文獻
- ^ PDB 2C93; Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J. Med. Chem. February 2006, 49 (4): 1346–55. PMID 16480269. doi:10.1021/jm050850v.
- ^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Mol. Genet. May 1987, 13 (3): 285–92. PMID 3474786. doi:10.1007/BF01535211.
- ^ Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. September 1987, 26 (19): 6165–77. PMID 2825773. doi:10.1021/bi00393a033.
深入閱讀
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外部連結
- The MEROPS online database for peptidases and their inhibitors: S01.217（頁面存檔備份，存於互聯網檔案館）
- GeneReviews/NCBI/NIH/UW entry on Prothrombin Thrombophilia（頁面存檔備份，存於互聯網檔案館）
- [3]（頁面存檔備份，存於互聯網檔案館） Anti-coagulation & proteases by The Proteolysis Map-animation
- [4] PMAP: The Proteolysis Map/Thrombin