UH-301

UH-301
識別資訊
	IUPAC命名法 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin; ;
CAS號	127126-22-1
IUPHAR/BPS	61;
UNII	1T7773JH5N;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID70155410 ;
化學資訊
化學式	C16H24FNO
摩爾質量	265.37 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES C2Cc1c(c(O)ccc1F)CC2N(CCC)CCC;

[S-]-UH-301，是一種科學研究中常用的研究化學品及藥物。是一種選擇性5-HT_1A 受體沉默拮抗劑。^[1]結構上與8-OH-DPAT相似。^[1] UH-301會令小鼠產生頭部抽搐反應，是5-HT_2A激動劑藥物的典型反應，因此可用來研究5-HT_1A受體活性如何調節下游5-HT_2A受體。^[2]

參見

參考文獻

^ ^1.0 ^1.1 Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.. J Pharmacol Exp Ther. 1991, 258 (1): 58–65. PMID 1830099.
^ Darmani, N. A.; Reeves, S. L. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology Biochemistry and Behavior. 1996, 55 (1): 1–10. PMID 8870031. doi:10.1016/0091-3057(96)00072-X.

[pmid1830099-1] 1.0 ^1.1 Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.. J Pharmacol Exp Ther. 1991, 258 (1): 58–65. PMID 1830099.

[2] Darmani, N. A.; Reeves, S. L. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology Biochemistry and Behavior. 1996, 55 (1): 1–10. PMID 8870031. doi:10.1016/0091-3057(96)00072-X.

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