納米魯單抗 (INN :namilumab;開發代號:MT203 ),或譯那美蘆單抗 ,是一種人單株抗體 (IgG1 κ 類),靶向粒細胞-巨噬細胞集落刺激因子 (簡稱GM-CSF或CSF2),目前正在研究用於類風濕性關節炎 和銀屑病關節炎 。[ 1] [ 2] [ 3] 納米魯單抗正在進行I期和II期臨床試驗,以確定該抗體在斑塊型銀屑病 [ 4] 和類風濕性關節炎中的安全性、耐受性和初步治療效用。[ 5] [ 6]
納米魯單抗由武田製藥 國際公司開發並由Micromet Inc生產。[ 3] [ 7]
參考資料
^ World Health Organization . International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 104 (PDF) . WHO Drug Information. 2010, 24 (4).
^ Huizinga T, Batalov A, Stoilov R, Lloyd E, Wagner T, Saurigny D, Souberbielle B, Esfandiari E. Namilumab, an Anti-Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Monoclonal Antibody: Results of the First Study in Patients with Mild-to-Moderate Rheumatoid Arthritis (RA): Abstract Number: 969 . Arthritis & Rheumatology. October 2015, 67 .
^ 3.0 3.1 Namilumab . Adis Insight. Springer Nature Switzerland AG. [2017-03-24 ] .
^ Clinical trial number NCT02129777 for "Efficacy and Safety of Namilumab (MT203) for Plaque Psoriasis" at ClinicalTrials.gov
^ A 24-week Randomized, Open-Label, Parallel-Group, Active-Controlled, Exploratory, Proof-of-Mechanism Imaging Study Investigating the Efficacy of 150 mg of Namilumab Administered Subcutaneously vs Adalimumab in Patients With Moderate to Severe Early Rheumatoid Arthritis Inadequately Responding to Methotrexate . Adis Insight. Springer Nature Switzerland AG. [2017-03-24 ] .
^ Clinical trial number NCT02379091 for "Dose Finding Study of Namilumab in Combination With Methotrexate in Participants With Moderate to Severe Rheumatoid Arthritis (RA)" at ClinicalTrials.gov
^ Namilumab . Takeda clinical trials summary.
趨化因子受體 集落刺激因子 (CSF)
細胞因子受體
IFNAR (α/β, I)
激動劑: Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (IFNB1 , IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II) IFNLR (λ, III)
白介素受體 TGFβ型受體 (TGFβ)TNF受體超家族 (TNFRSF)其它