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甲基硝基亞硝基胍

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甲基硝基亞硝基胍[1]
Structural formula of methylnitronitrosoguanidine
Space-filling model of the methylnitronitrosoguanidine molecule
IUPAC名
N-Methyl-N′-nitro-N-nitrosoguanidine
別名 1-Methyl-3-nitro-1-nitrosoguanidine
N-Methyl-N-nitroso-N′-nitroguanidine
識別
縮寫 MNNG
CAS號 70-25-7  checkY
PubChem 6261
ChemSpider 6025
SMILES
 
  • CN(C(=N[N+](=O)[O-])N)N=O
InChI
 
  • 1/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)
InChIKey VZUNGTLZRAYYDE-UHFFFAOYAT
KEGG C14592
性質
化學式 C2H5N5O3
摩爾質量 147.09 g/mol g·mol⁻¹
外觀 黃色晶體
熔點 118 °C(分解)
溶解性 reacts violently, slowly hydrolysed
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

甲基硝基亞硝基胍MNNG[2])是一種有機化合物,化學式為C2H5N5O3。這種生化試劑可用作致癌劑和致突變試劑

它在鹼性溶液中水解,生成重氮甲烷(DNA甲基化試劑),在酸性溶液中水解,生成亞硝酸[3]

參考文獻

  1. ^ Merck Index, 11th Edition, 6017.
  2. ^ Lawley, P. D.; Thatcher, Carolyn J. Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N′-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation. Biochemical Journal (Portland Press Ltd.). 1970-02-01, 116 (4): 693–707. ISSN 0306-3283. PMC 1185415可免費查閱. PMID 5435496. doi:10.1042/bj1160693. 
  3. ^ Hollaender, Alexander. Chemical Mutagens : Principles and Methods for Their Detection Volume 1. Boston, MA: Springer US. 1971: 188. ISBN 978-1-4615-8966-2. OCLC 851813793.