促腎上腺皮質素釋放素

促皮質素釋放激素
已知的結構
PDB	直系同源搜尋: PDBe RCSB
PDBID列表
	3EHU、3EHT、1GOE
識別號
別名	CRH；, CRF, CRH1, corticotropin releasing hormone
外部ID	OMIM：122560 MGI：88496 HomoloGene：599 GeneCards：CRH
基因位置（人類）
染色體	8號染色體
終止	66,178,464 bp
基因位置（小鼠）
染色體	小鼠3號染色體
終止	19,749,560 bp
RNA表達模式
	; ;
	查閱更多表達數據
基因本體
分子功能	• hormone activity; • corticotropin-releasing hormone receptor 1 binding; • corticotropin-releasing hormone receptor 2 binding; • 血漿蛋白結合; • neuropeptide hormone activity; • signaling receptor binding; • corticotropin-releasing hormone activity;
細胞組分	• 細胞質; • 細胞本體; • varicosity; • 細胞外區域; • soma; • 細胞外空間;
生物學過程	• response to cocaine; • response to immobilization stress; • positive regulation of cortisol secretion; • steroid metabolic process; • positive regulation of protein phosphorylation; • negative regulation of luteinizing hormone secretion; • positive regulation of cell death; • 聯想型學習; • ion homeostasis; • lung development; • diterpenoid metabolic process; • response to corticosterone; • female pregnancy; • negative regulation of norepinephrine secretion; • adrenal gland development; • synaptic transmission, dopaminergic; • negative regulation of cell death; • negative regulation of gene expression; • cellular response to dexamethasone stimulus; • positive regulation of corticosterone secretion; • response to estrogen; • locomotory exploration behavior; • regulation of NMDA receptor activity; • regulation of serotonin secretion; • positive regulation of calcium ion import; • glucocorticoid biosynthetic process; • positive regulation of gene expression; • positive regulation of digestive system process; • 出生; • response to pain; • positive regulation of circadian sleep/wake cycle, wakefulness; • positive regulation of cell population proliferation; • 下丘腦的發生; • 學習和記憶; • hormone-mediated apoptotic signaling pathway; • positive regulation of insulin secretion involved in cellular response to glucose stimulus; • response to ethanol; • inflammatory response; • negative regulation of circadian sleep/wake cycle, REM sleep; • response to ether; • positive regulation of behavioral fear response; • 信號轉導; • cellular response to cocaine; • 長時程增強作用; • 化學性突觸傳遞; • negative regulation of epinephrine secretion; • negative regulation of glucagon secretion; • G protein-coupled receptor signaling pathway; • negative regulation of systemic arterial blood pressure; • positive regulation of cAMP-mediated signaling; • positive regulation of corticotropin secretion;
	Sources:Amigo / QuickGO
直系同源
	1392
	12918
	ENSG00000147571
	ENSMUSG00000049796
	P06850
	Q8CIT0
	NM_000756
	NM_205769
	NP_000747
	NP_991338
	維基數據
檢視/編輯人類	檢視/編輯小鼠

促腎上腺皮質素釋放素是一種能參與應激反應的肽激素，也是一種釋放激素（英語：Releasing and inhibiting hormones）。人類的促腎上腺皮質素釋放素由CRH基因編碼。 ^[5]促腎上腺皮質素釋放素主要功能是可以刺激垂體合成促腎上腺皮質激素。

參考文獻

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000147571 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000049796 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Entrez Gene: CRH corticotropin releasing hormone.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000147571 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000049796 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] Entrez Gene: CRH corticotropin releasing hormone.

[1]

[2]

[3]

[4]

[5]