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H1299細胞

維基百科,自由的百科全書

H1299 (也稱為NCI-H1299[1]CRL-5803) 是源自淋巴結的人類非小細胞肺癌英語Non-small-cell lung carcinoma細胞系,在研究中得到廣泛應用[2]。H1299細胞與其他永生細胞系一樣可以無限期分裂,並且因p53基因的純合子部分缺失,故而不表達腫瘤抑制基因p53蛋白,說明了它們的增殖傾向[3]。有研究指出這些細胞會分泌神經調節素B英語Neuromedin B,但是不會分泌GRP[2]

參考資料

  1. ^ NCI-Navy Medical Oncology Branch cell line supplement.. Journal of cellular biochemistry. Supplement. 1996, 24: 1–291 [2019-11-29]. PMID 8965489. 
  2. ^ 2.0 2.1 Giaccone, G; Battey, J; Gazdar, AF; Oie, H; Draoui, M; Moody, TW. Neuromedin B is present in lung cancer cell lines.. Cancer research. 1992-05-01, 52 (9 Suppl): 2732s–2736s [2019-11-29]. PMID 1563005. 
  3. ^ Lin, DL; Chang, C. p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily.. The Journal of biological chemistry. 1996-06-21, 271 (25): 14649–52 [2019-11-29]. PMID 8663350. doi:10.1074/jbc.271.25.14649. 

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