α-萘黃酮
| α-萘黃酮 | |
|---|---|
| |
| IUPAC名 2-phenylbenzo[h]chromen-4-one | |
| 別名 | 7,8-Benzoflavone, ANF,2-phenylbenzo[h]chromen-4-one |
| 識別 | |
| CAS號 | 604-59-1 
|
| PubChem | 11790 |
| ChemSpider | 11297 |
| SMILES |
|
| InChI |
|
| InChIKey | VFMMPHCGEFXGIP-UHFFFAOYAW |
| ChEBI | 76995 |
| DrugBank | DB07453 |
| 性質 | |
| 化學式 | C19H12O2 |
| 摩爾質量 | 272.3 g·mol−1 |
| 若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。 | |
α-萘黃酮（又稱7,8-苯並黃酮）是一種人工合成的[1][2]黃酮類衍生物，可以由2-萘酚和肉桂醛製備而成。[3]
α-萘黃酮是一種強效的芳香化酶抑制劑，[1][2]實驗發現其能導致幼雞的睾丸發育出現異常。[4]
參見
參考資料
- ^ 1.0 1.1 Campbell, Deborah R.; Kurzer, Mindy S. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. Journal of Steroid Biochemistry and Molecular Biology. 1993, 46 (3): 381–388. PMID 9831487. doi:10.1016/0960-0760(93)90228-O.
- ^ 2.0 2.1 Kellis JT Jr; Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science. 1984, 225 (4666): 1032–1034. Bibcode:1984Sci...225.1032K. PMID 6474163. doi:10.1126/science.6474163.
- ^ Harvey, Ronald G.; Hahn, Jung Tai; Bukowska, Maria; Jackson, Henry. A new chromone and flavone synthesis and its utilization for the synthesis of potentially antitumorigenic polycyclic chromones and flavones. The Journal of Organic Chemistry. 1990, 55 (25): 6161. doi:10.1021/jo00312a023.
- ^ Trefil, P.; Micakova, A.; Stiborova, M.; Poplstein, M.; Brillard, J.P.; Hodek, P. Effects of alpha-naphthoflavone on body growth and gonad development in chickens (Gallus domesticus). Czech Journal of Animal Science - UZPI. 2004, 49 (6): 231–238. doi:10.17221/4305-CJAS.