麦芽糖酶-葡糖淀粉酶
麦芽糖酶-葡糖淀粉酶（英语：Maltase-glucoamylase）是一种由人体 MGAM 基因编码的酶。[6][7]
麦芽糖酶-葡糖淀粉酶是α-葡糖苷酶消化酶。它由两个具有不同底物特异性的亚基组成。 重组酶研究表明，其N-末端催化结构域对麦芽糖具有最高活性，而C-末端结构域具有更广泛的底物特异性和对葡萄糖寡聚体的活性。[8] 在小肠中，这种酶与蔗糖-异麦芽糖酶和α-淀粉酶协同作用，以消化各种淀粉。
延伸阅读
- Nichols BL, Avery S, Sen P, et al. The maltase-glucoamylase gene: common ancestry to sucrase-isomaltase with complementary starch digestion activities.. Proc. Natl. Acad. Sci. U.S.A. 2003, 100 (3): 1432–7. PMC 298790
. PMID 12547908. doi:10.1073/pnas.0237170100. - Takeshita F, Ishii KJ, Kobiyama K, et al. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF.. Eur. J. Immunol. 2005, 35 (8): 2477–85. PMID 16052631. doi:10.1002/eji.200526151.
- Hillier LW, Fulton RS, Fulton LA, et al. The DNA sequence of human chromosome 7.. Nature. 2003, 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
- Danielsen EM. Tyrosine sulfation, a post-translational modification of microvillar enzymes in the small intestinal enterocyte.. EMBO J. 1987, 6 (10): 2891–6. PMC 553723 . PMID 3121301.
- Korpela MP, Paetau A, Löfberg MI, et al. A novel mutation of the GAA gene in a Finnish late-onset Pompe disease patient: clinical phenotype and follow-up with enzyme replacement therapy.. Muscle Nerve. 2009, 40 (1): 143–8. PMID 19472353. doi:10.1002/mus.21291.
- Sim L, Quezada-Calvillo R, Sterchi EE, et al. Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity.. J. Mol. Biol. 2008, 375 (3): 782–92. PMID 18036614. doi:10.1016/j.jmb.2007.10.069.
- Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Naim HY, Sterchi EE, Lentze MJ. Structure, biosynthesis, and glycosylation of human small intestinal maltase-glucoamylase.. J. Biol. Chem. 1988, 263 (36): 19709–17. PMID 3143729.
- Ao Z, Quezada-Calvillo R, Sim L, et al. Evidence of native starch degradation with human small intestinal maltase-glucoamylase (recombinant).. FEBS Lett. 2007, 581 (13): 2381–8. PMID 17485087. doi:10.1016/j.febslet.2007.04.035.
- Tuğrul S, Kutlu T, Pekin O, et al. Clinical, endocrine, and metabolic effects of acarbose, an alpha-glucosidase inhibitor, in overweight and nonoverweight patients with polycystic ovarian syndrome.. Fertil. Steril. 2008, 90 (4): 1144–8. PMID 18377903. doi:10.1016/j.fertnstert.2007.07.1326.
参考文献
- ^ 對Maltase-glucoamylase起作用的藥物；在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000257335、ENSG00000282607 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000068587 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Entrez Gene: maltase-glucoamylase (alpha-glucosidase).
- ^ Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E. Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. J. Biol. Chem. January 1998, 273 (5): 3076–81. PMID 9446624. doi:10.1074/jbc.273.5.3076.
- ^ Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit. J. Nutr. 2008, 138 (4): 685–92. PMID 18356321.