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多巴胺受體D2

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多巴胺受体D2
已知的结构
PDB直系同源搜索: PDBe RCSB
识别号
别名DRD2；, D2DR, D2R, dopamine receptor D2
外部IDOMIM：126450 MGI：94924 HomoloGene：22561 GeneCards：DRD2
相关疾病
重性抑郁障碍[1]
为以下药物的标靶
remoxipride[2]
benzquinamide、​LP-12、​LP-211、​LP-44、​罗匹尼罗、​罗替戈汀、​维拉佐酮、​7-hydroxy-2-(di-N-propylamino)tetralin、​溴隐亭、​多巴胺、​培高利特、​普拉克索、​quinelorane、​quinpirole、​苏马尼罗、​阿朴吗啡、​阿立哌唑、​brexpiprazole、​过乳降、​麦角乙脲、​吡贝地尔、​roxindole、​特麦角脲、​氨磺必利、​布南色林、​布他拉莫、​氯丙嗪、​氯氮平、​多潘立酮、​eticlopride、​三氟噻吨、​氟奋乃静、​氟哌啶醇、​L-741,626、​洛沙平、​mesoridazine、​那法道曲、​奥氮平、​perospirone、​奋乃静、​匹莫齐特、​pipotiazine、​普乐明、​丙嗪、​喹硫平、​raclopride、​利培酮、​sertindole、​舒必利、​levosulpiride、​三氟拉嗪、​齐拉西酮、​zotepine[3]
基因位置（人类）
11号染色体
染色体11号染色体[4]
11号染色体
多巴胺受体D2的基因位置
多巴胺受体D2的基因位置
基因座11q23.2起始113,409,605 bp[4]
终止113,475,691 bp[4]
RNA表达模式




查阅更多表达数据
直系同源
物种人类小鼠
Entrez

1813

13489

Ensembl

ENSG00000149295

ENSMUSG00000032259

UniProt

P14416

P61168

mRNA​序列

NM_016574
​NM_000795

NM_010077

蛋白序列

NP_000786
​NP_057658
NP_000786.1

NP_034207

基因位置​（UCSC）Chr 11: 113.41 – 113.48 MbChr 9: 49.25 – 49.32 Mb
PubMed​查找[6][7]
维基数据
查看/编辑人类查看/编辑小鼠

多巴胺受体D2（Dopamine receptor D2，简称D2R），为转译自 DRD2 基因的一种多巴胺受体蛋白。D2R最早于1975年为Philip Seeman（英语：Philip Seeman）所发现，并将其命名为“抗精神疾患性多巴胺受体”（antipsychotic dopamine receptor）[8]。D2R为所有抗精神病药物的作用标的。

功能

D2R属于一种多巴胺受体，并会与Gi结合。Gi为G蛋白偶联受体的一种亚型，会抑制腺苷酸环化酶的活性[9]。

在小鼠模式中，齿状回的neuronal calcium sensor-1（英语：neuronal calcium sensor-1）（NCS-1）会影响D2R在细胞膜的表现量。这项机制会影响突触可塑性及记忆形成[10]。

在苍蝇模式中，多巴胺性神经元上的D2R自体受器（英语：autoreceptor）能避免神经元死亡，进而引发类帕金森氏症的症状[11]。

同型体

此基因的选择性剪接产生三种不同编码亚型的转录变体。[12]

长形式（D2Lh）具有"规范"的序列，并作为经典突触后蛋白发挥作用。[13]短形式（D2Sh）在突触前作为调节突触间隙中多巴胺水平的自身受体发挥作用。[13]D2Sh受体激动时抑制多巴胺释放，拮抗时增加多巴胺释放。[13]第三种D2（更长）的形式不同于270V被VVQ取代的规范序列。[14]

基因组

等位基因变异：

Some researchers have previously associated the polymorphism Taq 1A (rs1800497) to the DRD2 gene. However, the polymorphism resides in exon 8 of the ANKK1（英语：ANKK1） gene.[18]DRD2 TaqIA polymorphism has been reported to be associated with an increased risk for developing motor fluctuations but not hallucinations in Parkinson's disease.[19][20]

配体

大多数较老的抗精神病药如氯丙嗪或氟哌啶醇是多巴胺D2受体的非选择性拮抗剂，最多仅对"D2样家族"受体具有选择性，因此与D2、D3、D4以及许多其他受体都可以结合，例如血清素和组胺受体，导致一系列副作用使得它们不适合科学研究。类似，用于治疗帕金森病的较旧的多巴胺激动剂例如溴隐亭和卡麦角林，对一种多巴胺受体的选择性较差，尽管这些药物中大多数确实能起到D2激动剂的作用，但它们也会影响其他多巴胺受体，亚型也是。现今有几种选择性D2配体 (生物化学)可以使用，并且随着进一步的研究，这个数字可能会增加。

受体致活剂

部分受体致活剂

受体拮抗剂

D2sh selective (presynaptic autoreceptors)

异位调控因子

Functionally selective ligands

  • 参见参考文献[31]。

Protein–protein interactions

多巴胺受体 D2 已被证明与EPB41L1（英语：EPB41L1）、[32]PPP1R9B（英语：PPP1R9B）[33] 和 NCS-1（英语：NCS-1） 相互作用。[34]

Receptor oligomers

The D2 receptor forms receptor heterodimers（英语：GPCR oligomer） in vivo (in living animals) with other G protein-coupled receptors; these include:[35]

The D2 receptor has been shown to form hetorodimers in vitro (and possibly in vivo) with DRD3（英语：Dopamine D3 receptor）,[38]DRD5（英语：Dopamine receptor D5）,[39]and 5-HT2A（英语：5-HT2A receptor）.[40]

注释

  1. ^ D2sh–TAAR1 is a presynaptic heterodimer which involves the relocation of TAAR1 from the intracellular space to D2sh at the plasma membrane, increased D2sh agonist binding affinity, and signal transduction through the calcium–PKC–NFAT pathway and G-protein independent PKB–GSK3（英语：GSK3） pathway.[36][37]

参考文献

  1. ^ 與多巴胺受體D2相關的疾病；在維基數據上查看/編輯參考. 
  2. ^ 對Dopamine receptor D2, isoform CRA_c起作用的藥物；在維基數據上查看/編輯參考. 
  3. ^ 對Dopamine receptor D2起作用的藥物；在維基數據上查看/編輯參考. 
  4. ^ 4.0 4.1 4.2 GRCh38: Ensembl release 89: ENSG00000149295 - Ensembl, May 2017
  5. ^ 5.0 5.1 5.2 GRCm38: Ensembl release 89: ENSMUSG00000032259 - Ensembl, May 2017
  6. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  7. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  8. ^ Madras BK. History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia. Journal of the History of the Neurosciences. 2013, 22 (1): 62–78. PMID 23323533. doi:10.1080/0964704X.2012.678199. 
  9. ^ Usiello A, Baik JH, Rougé-Pont F, Picetti R, Dierich A, LeMeur M, Piazza PV, Borrelli E. Distinct functions of the two isoforms of dopamine D2 receptors. Nature. Nov 2000, 408 (6809): 199–203. PMID 11089973. doi:10.1038/35041572. 
  10. ^ Saab BJ, Georgiou J, Nath A, Lee FJ, Wang M, Michalon A, Liu F, Mansuy IM, Roder JC. NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. Neuron. Sep 2009, 63 (5): 643–56. PMID 19755107. doi:10.1016/j.neuron.2009.08.014. 
  11. ^ Wiemerslage L, Schultz BJ, Ganguly A, Lee D. Selective degeneration of dopaminergic neurons by MPP(+) and its rescue by D2 autoreceptors in Drosophila primary culture. Journal of Neurochemistry. Aug 2013, 126 (4): 529–40. PMID 23452092. doi:10.1111/jnc.12228. 
  12. ^ Entrez Gene: DRD2 dopamine receptor D2. （原始内容存档于2010-03-07）. 
  13. ^ 13.0 13.1 13.2 Beaulieu JM, Gainetdinov RR. The physiology, signaling, and pharmacology of dopamine receptors. Pharmacological Reviews. Mar 2011, 63 (1): 182–217. PMID 21303898. doi:10.1124/pr.110.002642. 
  14. ^ UniProt P14416
  15. ^ Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Human Molecular Genetics. Feb 2003, 12 (3): 205–16. PMID 12554675. doi:10.1093/hmg/ddg055. 
  16. ^ Arinami T, Gao M, Hamaguchi H, Toru M. A functional polymorphism in the promoter region of the dopamine D2 receptor gene is associated with schizophrenia. Human Molecular Genetics. Apr 1997, 6 (4): 577–82. PMID 9097961. doi:10.1093/hmg/6.4.577. 
  17. ^ Glatt SJ, Faraone SV, Tsuang MT. DRD2 -141C insertion/deletion polymorphism is not associated with schizophrenia: results of a meta-analysis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. Jul 2004, 128B (1): 21–3. PMID 15211624. doi:10.1002/ajmg.b.30007. 
  18. ^ Lucht M, Rosskopf D. Comment on "Genetically determined differences in learning from errors". Science. Jul 2008, 321 (5886): 200; author reply 200. PMID 18621654. doi:10.1126/science.1155372. 
  19. ^ Wang J, Liu ZL, Chen B. Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD. Neurology. Jun 2001, 56 (12): 1757–9. PMID 11425949. doi:10.1212/WNL.56.12.1757. 
  20. ^ Wang J, Zhao C, Chen B, Liu ZL. Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease. Neuroscience Letters. Jan 2004, 355 (3): 193–6. PMID 14732464. doi:10.1016/j.neulet.2003.11.006. 
  21. ^ Clinical Pharmacology for Abilify. RxList.com. 2010-01-21 [2010-01-21]. （原始内容存档于2010-01-18）. 
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  23. ^ Giacomelli S, Palmery M, Romanelli L, Cheng CY, Silvestrini B. Lysergic acid diethylamide (LSD) is a partial agonist of D2 dopaminergic receptors and it potentiates dopamine-mediated prolactin secretion in lactotrophs in vitro. Life Sciences. 1998, 63 (3): 215–22. PMID 9698051. doi:10.1016/S0024-3205(98)00262-8. 
  24. ^ Wang GJ, Volkow ND, Thanos PK, Fowler JS. Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review. Journal of Addictive Diseases. 2004, 23 (3): 39–53. PMID 15256343. doi:10.1300/J069v23n03_04. 
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  26. ^ Agnati LF, Ferré S, Genedani S, Leo G, Guidolin D, Filaferro M, Carriba P, Casadó V, Lluis C, Franco R, Woods AS, Fuxe K. Allosteric modulation of dopamine D2 receptors by homocysteine. Journal of Proteome Research. Nov 2006, 5 (11): 3077–83. PMID 17081059. doi:10.1021/pr0601382. 
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  36. ^ Grandy DK, Miller GM, Li JX. "TAARgeting Addiction"-The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference. Drug Alcohol Depend. February 2016, 159: 9–16. PMID 26644139. doi:10.1016/j.drugalcdep.2015.11.014. This original observation of TAAR1 and DA D2R interaction has subsequently been confirmed and expanded upon with observations that both receptors can heterodimerize with each other under certain conditions ... Additional DA D2R/TAAR1 interactions with functional consequences are revealed by the results of experiments demonstrating that in addition to the cAMP/PKA pathway (Panas et al., 2012) stimulation of TAAR1-mediated signaling is linked to activation of the Ca++/PKC/NFAT pathway (Panas et al.,2012) and the DA D2R-coupled, G protein-independent AKT/GSK3 signaling pathway (Espinoza et al., 2015; Harmeier et al., 2015), such that concurrent TAAR1 and DA DR2R activation could result in diminished signaling in one pathway (e.g. cAMP/PKA) but retention of signaling through another (e.g., Ca++/PKC/NFA) 
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外部链接


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