右旋甲状腺素

右旋甲状腺素
临床资料
商品名（英语：Drug nomenclature）	Choloxin
其他名称	D-3,5,3',5'-tetraiodothyronine
AHFS/Drugs.com	Multum消费者信息
ATC码	C10AX01 (WHO) ;
法律规范状态
法律规范	Discontinued;
识别信息
	IUPAC命名法 (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid; ;
CAS号	51-49-0
PubChem CID	8730;
DrugBank	DB00509;
ChemSpider	8402;
UNII	4W9K63FION;
ChEBI	CHEBI:30659;
ChEMBL	ChEMBL559;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID60199000 ;
ECHA InfoCard	100.000.094
化学信息
化学式	C15H11I4NO4
摩尔质量	776.87 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O=C(O)[C@H](N)Cc2cc(I)c(Oc1cc(I)c(O)c(I)c1)c(I)c2;
	InChI InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1; Key:XUIIKFGFIJCVMT-GFCCVEGCSA-N;

右旋甲状腺素，英文：Dextrothyroxine，商品名：Choloxin，是甲状腺素的右旋异构体。^[1]起初该化合物被研发，以用于降胆固醇药物^[2]，但由于其心脏副作用而被退出市场。该药物会增加肝脂肪酶，从而提高甘油三酯的利用率并降低血清中脂蛋白（a）的水平。^[3]

参见

左旋甲状腺素

参考文献

^ Dextrothyroxine (Code C61719). NCI Thesaurus. National Cancer Institute. 2011-11-14 [2020-01-28]. （原始内容存档于2023-05-22）.
^ Bantle JP, Hunninghake DB, Frantz ID, Kuba K, Mariash CN, Oppenheimer JH. Comparison of effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine in treatment of hypercholesterolemia. The American Journal of Medicine. September 1984, 77 (3): 475–81. PMID 6475988. doi:10.1016/0002-9343(84)90107-4.
^ Bommer C, Werle E, Walter-Sack I, Keller C, Gehlen F, Wanner C, et al. D-thyroxine reduces lipoprotein(a) serum concentration in dialysis patients. Journal of the American Society of Nephrology. January 1998, 9 (1): 90–6. PMID 9440092.

[1] Dextrothyroxine (Code C61719). NCI Thesaurus. National Cancer Institute. 2011-11-14 [2020-01-28]. （原始内容存档于2023-05-22）.

[2] Bantle JP, Hunninghake DB, Frantz ID, Kuba K, Mariash CN, Oppenheimer JH. Comparison of effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine in treatment of hypercholesterolemia. The American Journal of Medicine. September 1984, 77 (3): 475–81. PMID 6475988. doi:10.1016/0002-9343(84)90107-4.

[3] Bommer C, Werle E, Walter-Sack I, Keller C, Gehlen F, Wanner C, et al. D-thyroxine reduces lipoprotein(a) serum concentration in dialysis patients. Journal of the American Society of Nephrology. January 1998, 9 (1): 90–6. PMID 9440092.

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