E0771

E0771是C57BL/6小鼠髓样乳腺癌 (Medullary breast adenocarcinoma) 细胞系，E0771细胞比4T1细胞具有更低的转移能力，目前应用于多项研究当中。

科研用途

E0771细胞通常应用于C57BL/6小鼠乳腺癌的体外和体内研究^[1]。在2015年及2017年，分别有科研人员研究SDG补充剂 (SDG supplementation) 对在体内生长的E0771细胞的影响，发现SDG补充剂抑制着E0771细胞的生长，并且降低了核因子活化B细胞κ轻链增强子的肿瘤活性^[2]^[3]。2019年，有研究探讨了白色脂肪组织褐变 (WAT褐变) 能否在体内的小鼠乳腺癌模型中发生，随后研究了特征明确的E0771细胞在体内的作用。实验结果证明在体外的E0771细胞诱导着白色脂肪细胞基因表达模式的改变。WAT褐变不会通过直接的E0771癌细胞机制而发生。这表明肿瘤微环境中的细胞相互作用是致热变化的潜在驱动力^[4]。

参考资料

^ Ewens, A; Mihich, E; Ehrke, MJ. Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma.. Anticancer research. NaN, 25 (6B): 3905–15 [2019-12-27]. PMID 16312045. （原始内容存档于2019-12-27）. 请检查|date=中的日期值 (帮助)
^ Johnstone, CN; Smith, YE; Cao, Y; Burrows, AD; Cross, RS; Ling, X; Redvers, RP; Doherty, JP; Eckhardt, BL; Natoli, AL; Restall, CM; Lucas, E; Pearson, HB; Deb, S; Britt, KL; Rizzitelli, A; Li, J; Harmey, JH; Pouliot, N; Anderson, RL. Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.. Disease models & mechanisms. 2015-03, 8 (3): 237–51 [2019-12-27]. PMID 25633981. doi:10.1242/dmm.017830. （原始内容存档于2019-12-27）.
^ Yang, Y; Yang, HH; Hu, Y; Watson, PH; Liu, H; Geiger, TR; Anver, MR; Haines, DC; Martin, P; Green, JE; Lee, MP; Hunter, KW; Wakefield, LM. Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.. Oncotarget. 2017-05-09, 8 (19): 30621–30643 [2019-12-27]. PMID 28430642. doi:10.18632/oncotarget.15695. （原始内容存档于2019-12-27）.
^ Pearce, JV; Farrar, JS; Lownik, JC; Ni, B; Chen, S; Kan, TW; Celi, FS. E0771 and 4T1 murine breast cancer cells and interleukin 6 alter gene expression patterns but do not induce browning in cultured white adipocytes.. Biochemistry and biophysics reports. 2019-07, 18: 100624 [2019-12-27]. PMID 31193642. doi:10.1016/j.bbrep.2019.100624.

外部链接

Cellosaurus entry for E0771（页面存档备份，存于互联网档案馆）

[1] Ewens, A; Mihich, E; Ehrke, MJ. Distant metastasis from subcutaneously grown E0771 medullary breast adenocarcinoma.. Anticancer research. NaN, 25 (6B): 3905–15 [2019-12-27]. PMID 16312045. （原始内容存档于2019-12-27）. 请检查|date=中的日期值 (帮助)

[2] Johnstone, CN; Smith, YE; Cao, Y; Burrows, AD; Cross, RS; Ling, X; Redvers, RP; Doherty, JP; Eckhardt, BL; Natoli, AL; Restall, CM; Lucas, E; Pearson, HB; Deb, S; Britt, KL; Rizzitelli, A; Li, J; Harmey, JH; Pouliot, N; Anderson, RL. Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.. Disease models & mechanisms. 2015-03, 8 (3): 237–51 [2019-12-27]. PMID 25633981. doi:10.1242/dmm.017830. （原始内容存档于2019-12-27）.

[3] Yang, Y; Yang, HH; Hu, Y; Watson, PH; Liu, H; Geiger, TR; Anver, MR; Haines, DC; Martin, P; Green, JE; Lee, MP; Hunter, KW; Wakefield, LM. Immunocompetent mouse allograft models for development of therapies to target breast cancer metastasis.. Oncotarget. 2017-05-09, 8 (19): 30621–30643 [2019-12-27]. PMID 28430642. doi:10.18632/oncotarget.15695. （原始内容存档于2019-12-27）.

[4] Pearce, JV; Farrar, JS; Lownik, JC; Ni, B; Chen, S; Kan, TW; Celi, FS. E0771 and 4T1 murine breast cancer cells and interleukin 6 alter gene expression patterns but do not induce browning in cultured white adipocytes.. Biochemistry and biophysics reports. 2019-07, 18: 100624 [2019-12-27]. PMID 31193642. doi:10.1016/j.bbrep.2019.100624.

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